6 documents found, page 1 of 1
Remission versus low disease activity as treatment targets in rheumatoid arthri...
Duarte, Cátia; Jacobs, Johannes W.G.; Ferreira, Ricardo J.O.; Welsing, Paco M.J.; Gossec, Laure; Machado, Pedro M.; van der Heijde, DésiréeObjectives: To evaluate the impact of using Simplified Disease Activity Index (SDAI)-LDA (low disease activity) versus different definitions of remission as a treatment target in established rheumatoid arthritis. Methods: A meta-epidemiological study of individual patient data from eight randomised controlled trials was performed. Four definitions of the target were considered at 6 months: (1) SDAI-LDA: SDAI≤11...
Remission definitions guiding immunosuppressive therapy in rheumatoid arthritis...
Duarte, Cátia; Ferreira, Ricardo J. O.; Welsing, Paco M.; Jacobs, Johannes W. G.; Gossec, Laure; Machado, Pedro M.; van der Heijde, DésiréeObjective: To assess which definition of remission best predicts good radiographic outcome (GRO) and good functional outcome (GFO) in rheumatoid arthritis, focusing the updated American College of Rheumatology/European Alliance of Associations for Rheumatology criteria. Material and methods: Meta-analyses of individual patient data (IPD) from randomised controlled trials (RCTs). Six definitions of remission wer...
Environmental and societal factors associated with COVID-19-related death in pe...
Izadi, Zara; Gianfrancesco, Milena A.; Schmajuk, Gabriela; Jacobsohn, Lindsay; Katz, Patricia; Rush, Stephanie; Ja, Clairissa; Taylor, TiffanyBackground: Differences in the distribution of individual-level clinical risk factors across regions do not fully explain the observed global disparities in COVID-19 outcomes. We aimed to investigate the associations between environmental and societal factors and country-level variations in mortality attributed to COVID-19 among people with rheumatic disease globally. Methods: In this observational study, we de...
Long‐term association between disease activity and disability in early axial Sp...
PD, Carvalho; Ruyssen‐Witrand, Adeline; Marreiros, Ana; Machado, Pedro M.Objective Our primary objective was to study the long-term association between disease activity and disability in axial spondyloarthritis (SpA). Our secondary objective was to define patient profiles according to their level of disability. Methods We analyzed data collected during the first 5 years of follow-up of a large early axial SpA cohort, the Devenir des Spondylarthropathies Indifferenciees Recentes (DES...
SARS-CoV-2 outbreak in immune-mediated inflammatory diseases : the Euro-COVIMID...
Saadoun, David; Vieira, Matheus; Vautier, Mathieu; Baraliakos, Xenofon; Andreica, Ioana; da Silva, José A. P.; Sousa, Marlene; Luis, MarianaBackground: The COVID-19 pandemic has raised numerous questions among patients with immune-mediated inflammatory diseases regarding potential reciprocal effects of COVID-19 and their underlying disease, and potential effects of immunomodulatory therapy on outcomes related to COVID-19. The seroprevalence of SARS-CoV-2 and factors associated with symptomatic COVID-19 in patients with immune-mediated inflammatory ...
Prevalence of rheumatic and musculoskeletal diseases and their impact on health...
Branco, Jaime C.; Rodrigues, Ana M.; Gouveia, Nélia; Eusébio, Mónica; Ramiro, Sofia; Machado, Pedro M.; Costa, Leonor Pereira da; Mourão, Ana FilipaObjectives To estimate the national prevalence of rheumatic and musculoskeletal diseases (RMDs) in the adult Portuguese population and to determine their impact on health-related quality of life (HRQoL), physical function, anxiety and depression. Methods EpiReumaPt is a national health survey with a three-stage approach. First, 10 661 adult participants were randomly selected. Trained interviewers undertook str...