6 documents found, page 1 of 1
Biosurfactant production during saline oilfield produced water treatment: a pro...
Silva, Ana Rita Almendra; Gudiña, Eduardo José; Oliveira, Renata Fernandes; Machado, Raúl; Rodrigues, L. R.; Pereira, M. A.Considerable efforts have been made by the oil industry to develop sustainable strategies for managing produced water (PW) and enhancing oil recovery. This study evaluated biosurfactant (BS) production during PW treatment (0.26 g L1 of total petroleum hydrocarbon (TPH) and 3.5% salinity) using Alcanivorax borkumensis SK2 as an inoculum. In batch experiments (24 and 96 h of incubation), nitrogen concentration wa...
Nanotechnology and nature-sourced ingredients for tackling neurodegenerative di...
Rocha, Verónica Patrícia Moreira; Ribeiro, Joana; Machado, Raúl; Gomes, Andreia CNeurodegenerative diseases (NDDs) pose a significant and pressing societal challenge in the twenty-first century, demanding immediate attention. Innovative approaches are actively being explored in the quest for more effective NDDs therapies. The pipeline of potential medicines offers hope, encompassing disease-modifying drugs, symptomatic treatments, and regenerative strategies. In parallel, natural products d...
A label-free multitechnique approach to characterize the interaction of bioacti...
Fernandes, Eduarda; Costa, Rui Filipe Ramos; Machado, Raúl; Reis, R. L.; Pashkuleva, I.; Lúcio, MarleneExtensive research has been conducted on biomimetic interfaces mimicking the complex and diverse microenvironment of cell membranes to gain insights into bioactive compound interactions and membrane biophysics modulation. The present study proposes an innovative approach that combines five prospective label-free methodologies (derivative spectroscopy, synchrotron small- and wide-angle X-Ray scattering, attenuat...
Avobenzone-loaded and omega-3-enriched lipid formulations for production of UV ...
Caldas, Ana Rita; Faria, Maria João; Ribeiro, Artur; Machado, Raúl; Gonçalves, Hugo; Gomes, Andreia C.; Soares, Graça; Lopes, Carla MartinsGiven the growing harmful effects of ultraviolet (UV) radiation there is an urgent need to develop effective strategies to prevent skin damages. Therefore, hydrogel or cotton and wool fabrics were impregnated with avobenzone (AVO)-loaded and omega-3 (ω3)-enriched lipid formulations (liposomes – LIP, nanostructured lipid carriers – NLC and solid lipid nanoparticles – SLN) to obtain UV blocking sunscreen gel or f...
Omega 3 and resveratrol loaded lipid nanosystems for potential use as topical f...
Caldas, Ana Rita; Catita, José; Machado, Raúl; Ribeiro, Artur; Cerqueira, Fátima; Horta, Bruno; Medeiros, R.; Lúcio, Marlene; Lopes, Carla MartinsResveratrol (RSV) and omega 3 (ω3), because of their biological favorable properties, have become subjects of interest for researchers in dermocosmetic and pharmaceutical industries; however, these bioactives present technological limitations that hinder their effective delivery to the target skin layer. To overcome the stability and skin permeation limitations of free bioactives, this work proposes a combined ...
Design of polymeric core-shell carriers for combination therapies
Silva, Dina M.; Liu, Ruy; Gonçalves, Anabela F.; da Costa, André; Gomes, Andreia C; Machado, Raúl; Vongsvivut, Jitraporn; Tobin, Mark J.Particle engineering for co-delivery of drugs has the potential to combine multiple drugs with different pharmaceutical mechanisms within the same carrier, increasing the therapeutic efficiency while improving patient compliance. This work proposes a novel approach for producing polymer–polymer core–shell microparticles by multi-step processing of emulsion and spray drying. The particle core was obtained by an ...