Encontrados 4 documentos, a visualizar página 1 de 1
Pattern of hemolysis parameters and association with fetal hemoglobin in sickle...
Moreira, Juliane Almeida; Laurentino, Marília Rocha; Machado, Rosângela Pinheiro Gonçalves; Barbosa, Maritza Cavalcante; Gonçalves, Ronaldo PinheiroObjective: This study aimed to evaluate the influence of fetal hemoglobin (Hb F) on hemolysis biomarkers in sickle cell anemia patients. Methods: Fifty adult sickle cell anemia patients were included in the study. All patients were taking hydroxyurea for at least six months and were followed at the outpatient clinic of a hospital in Fortaleza, Ceará, Brazil. The control group consisted of 20 hemoglobin AA indiv...
Clinical events and their relation to the tumor necrosis factor-alpha and inter...
Cavalcante, Jânio Emanuel Andrade; Machado, Rosângela Pinheiro Gonçalves; Laurentino, Marília Rocha; Santos, Talyta Ellen de Jesus dosObjective/background: Sickle-cell anemia (SCA) is a genetic blood disease characterized by chronic inflammation and a heterogeneous clinical picture. Serum tumor necrosis factor (TNF-alpha) and interleukin 10 (IL-10) levels are associated with the clinical course of SCA. This study aimed to evaluate the association between the frequency of the polymorphisms TNF- alpha-308 G ? A, IL-10-1082 G ? A, IL-10-819 C ? ...
Modulação genética do bcl11a no perfil inflamatório, hemolítico, estresse oxida...
Machado, Rosângela Pinheiro Gonçalves8 ABSTRACT Sickle cell disease (SCD) is an autosomal hereditary hemoglobinopathies caused by a point mutation in the beta globin gene generates an abnormal hemoglobin called hemoglobin S (Hb S) in homozygous. The disease is characterized by presenting a variability of symptoms, which is due to m ultiple factors, including fetal hemoglobin (HbF), the haplotypes of the beta globin gene and polymorphisms BCL11A ge...
Perfil clínico dos pacientes com LLC-B do Ambulatório do Hospital Universitário...
Machado, Rosângela Pinheiro GonçalvesIntroduction: Chronic lymphocytic leukemia (CLL) is a neoplasm characterized by clonal proliferation of lymphocytes of mature appearance. Clinically and prognostic heterogeneous. Rai and Binet established clinical prognostic systems that classify LLC in low, intermediate and high risk. Soon, the biological markers of prognosis that increased the predictive power of the LLC. Objective: To characterize the clinic...