4 documents found, page 1 of 1
Solid and aqueous magnetoliposomes as nanocarriers for a new potential drug act...
Rodrigues, Ana Rita Oliveira; Mendes, Pedro M. F.; Silva, Pedro M. L.; Machado, Vera Alexandra Pereira; Almeida, B. G.; Araújo, João P.Iron oxide nanoparticles, with diameters around 12 nm, were synthesized by coprecipitation method. The magnetic properties indicate a superparamagnetic behavior with a coercive field of 9.7 Oe and a blocking temperature of 118 K. Both aqueous and solid magnetoliposomes containing magnetite nanoparticles have sizes below 150 nm, suitable for biomedical applications. Interaction between both types of magnetolipos...
Synthesis of novel heterocyclic compounds based on rational design and evaluati...
Machado, Vera Alexandra PereiraThe synthesis of novel 1-aryl-3-[3- or 4-(thieno[3,2-b]pyridin-7-ylthio)phenyl]ureas was performed and they were first studied as potential antiangiogenics using Vascular Endothelium Growth Factor Receptor-2 (VEGFR-2) tyrosine kinase enzymatic assays. The most promising inhibitors, 1-aryl-3-[3-(thieno[3,2-b]pyridin-7-ylthio)phenyl]ureas, were also studied as antiangiogenics in endothelial cells (HUVECs) and as ...
Synthesis, molecular docking and biological Evaluation of New 1-Aryl-3-[3-(thie...
Machado, Vera Alexandra Pereira; Peixoto, Daniela Alexandra Silva; Costa, Raquel; Calhelha, Ricardo C.; Abreu, Rui M. V.; Ferreira, Isabel C. F. R.
Efeito de novas di(hetero)arilaminas sintéticas na prevenção de danos e morte c...
Machado, Vera Alexandra PereiraA produção excessiva de espécies reactivas de oxigénio (ROS) leva a uma situação de stresse oxidativo onde danos nas principais biomoléculas resultam na morte celular contribuindo para o desenvolvimento de várias patologias. Deste modo, é importante o desenvolvimento de novos compostos capazes de proteger as células destes níveis excessivos de radicais livres, para além das suas defesas naturais. Neste estudo f...