8 documents found, page 1 of 1
Are cranberry capsules effective and safe in preventing urinary tract infection...
Pereira,Tiago Assis; Fernandes,Ana Raquel; Mendes,Artur; Oliveira,Regina; Casqueiro,Ana; Birne,Rita; Matias,Patrícia; Jorge,Cristina; Adragão,TeresaIntroduction: Kidney transplant (KT) recipients are highly susceptible to urinary tract infections (UTIs). Few data are available regarding the effects of cranberry products in KT recipients. Subjects and methods: This was a randomized double-blind study comparing daily treatment with a cranberry capsule versus a placebo capsule for 6 months. The study protocol was conducted in accordance with the Helsinki Decl...
IgA nephropathy in a young adult with nephrotic syndrome: Case report
Cassis,João; Sousa,Henrique Silva; Manso,Rita Theias; Ramos,Sância; Machado,DomingosIgA nephropathy has many clinical presentations, of which nephrotic syndrome is possibly the rarest. Recently, the association of IgA nephropathy with minimal change disease was better described with patients having complete response to steroid therapy and no progression to CKD. We report a similar case in a young male presenting with nephrotic syndrome
Benefits of selective vitamin D receptor activators in kidney transplanted pati...
Ferreira,Aníbal; Aires,Inês; Nolasco,Fernando; Machado,Domingos; Macário,Fernando; Neves,Pedro L.; Costa,António G.; Cabrita,António M. N.; Castro,RuiSevere chronic kidney disease may lead to disturbances, such as hyperphosphatemia, increased secretion of fibroblast growth factor-23 (FGF-23) and vitamin D deficiency. These may increase plasmatic levels of parathyroid hormone, and decrease plasmatic levels of calcium. Altogether, these may contribute to the development of secondary hyperparathyroidism, and to abnormalities in mineral metabolism. Kidney transp...
Pregnancy in renal transplanted patients: effects on the mother and the newborn...
Cândido,Cristina; Viegas,Márcio; Matias,Patrícia; Birne,Rita; Jorge,Cristina; Weigert,André; Adragão,Teresa; Bruges,Margarida; Machado,DomingosBackground: Chronic kidney disease causes decreased fertility. With kidney transplantation, fertility is restored within a few months. Objective: To analyse the feasibility of pregnancy with renal transplantation and its impact on renal function, complications in women and newborns. Methods: Retrospective study of pregnancies that occurred in kidney transplant recipients between 1985 and 2014 in one Transplanta...
Mineral and Bone Disease (MBD)
Birne,Rita; Adragão,Teresa; Ferreira,Aníbal; Dickson,Jorge; Silva,Rui; Casqueiro,Ana; Oliveira,Regina; Martins,Ana Rita; Torres,João; Matias,PatríciaA 50-year-old post-menopausal recipient of a kidney allograft with bone pain, osteoporosis, persistent hypercalcaemia and elevated parathormone (PTH) levels, despite a satisfactory graft function, was treated with bisphosphonates and cinacalcet starting, respectively, 5 and 6 months after renal transplantation (RT). Sixteen months after treatment, there was improvement of bone mineral density (BMD) measured by ...
Inhibitors of the mammalian target of rapamycin in kidney transplantation: impa...
Farinha,Ana; Matias,Patrícia; Jorge,Cristina; Bruges,Margarida; Adragão,Teresa; Birne,Rita; Weigert,André; Machado,DomingosBackground: Inhibitors of the mammalian target of rapamycin (mTOR) have demonstrated a similar outcome on allograft loss but its impact on patient survival has only recently been evaluated. In this outcome analysis all renal transplants performed at our unit since 1/1/2006 until 12/31/2011, were evaluated. Allograft failure and mortality were compared between patients who were converted to mTOR and those who re...
Renal transplantation in an HIV-2 positive recipient in Portugal
Natário,Ana; Rodrigues,Bruno; Matias,Patrícia; Jorge,Cristina; Bruges,Margarida; Birne,Rita; Miranda,Ana; Mansinho,Kamal; Machado,DomingosThe improvement of combined antiretroviral therapy regimens has made solid organ transplantation a therapeutic option for patients with human immunodeficiency virus (HIV) infection. Generally, HIV-2 infectionpresents a slower clinical progression and immunological degradation than HIV-1. HIV-2 infection treatment can be challenging when a complex immunosuppressive regimen is combined with antiretroviraltherapy....
Bortezomib in the treatment of refractory kidney graft rejection
Farinha,Ana; Jorge,Cristina; Weigert,André; Bruges,Margarida; Birne,Rita; Matias,Patrícia; Adragão,Teresa; Machado,DomingosBackground. Bortezomib, a 26S proteasome inhibitor, is a novel treatment for refractory acute rejection. The main mechanism proposed for its action is the induction of apoptosis of mature plasma cells leading to an interruption of donor-specific antibody production, but other properties may also be involved. Patients and Methods. Four patients presenting with antibody-mediated rejection were treated with bortez...