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The Growing Landscape of NAFLD-Associated Hepatocellular Carcinoma and Its Impa...

Machado,Mariana Verdelho

Abstract Liver cancer is globally the third leading cause of death from cancer. Hepatocellular carcinoma (HCC) develops in patients with underlying liver disease. The fraction of HCC attributed to nonalcoholic fatty liver disease (NAFLD) shows an accelerated increase in the last decades, being already responsible for 15% of all HCC cases. Similar to other causes of liver cirrhosis, patients with NAFLD-associate...

Date: 2024   |   Origin: SciELO Portugal

Celiac Disease Revisited

Calado,João; Machado,Mariana Verdelho

Abstract Celiac disease (CD) is a systemic disease triggered by gluten ingestion in genetically predisposed individuals. It manifests primarily as an autoimmune enteropathy associated with specific circulating autoantibodies and a human leukocyte antigen haplotype (HLA-DQ2 or HLA-DQ8). It afflicts roughly 1% of the population, though the majority of patients remain undiagnosed. Diarrhea and malabsorption are cl...

Date: 2022   |   Origin: SciELO Portugal

Secondary Sclerosing Cholangitis in Critically Ill Patients: An Underdiagnosed ...

Martins,Pedro; Machado,Mariana Verdelho

Secondary sclerosing cholangitis in critically ill patients (SSCCIP) is a recently identified cholestatic liver disease occurring in patients without prior history of hepatobiliary disease, after receiving treatment in the intensive care unit (ICU) in different settings, including cardiothoracic surgery, infection, trauma, and burns. It is a rare entity, being estimated to occur in 1/2,000 patients in an ICU; h...

Date: 2020   |   Origin: SciELO Portugal



A Bugs Battle on Behalf of the Liver

Machado,Mariana Verdelho

Date: 2016   |   Origin: SciELO Portugal

Diarreia Associada a Clostridium Difficile num Hospital Central

Vieira,Ana Margarida; Machado,Mariana Verdelho; Lito,Luís; Cristino,José Melo; Fernandes,Afonso; Maldonado,Rosário; Valente,Ana; Palma,Rui

INTRODUÇÃO: Tem-se assistido a um aumento da incidência da diarreia associada ao Clostridium difficile (DACD) e ao aparecimento de estirpes de maior virulência. OBJECTIVOS: O objectivo do estudo foi a caracterização epidemiológica e clínica dos doentes adultos, internados consecutivamente, por DACD, num hospital central. MATERIAL E MÉTODOS: Análise retrospectiva dos doentes internados, em que se efectuou o diag...

Date: 2010   |   Origin: SciELO Portugal

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