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Cell cycle regulation of hippocampal progenitor cells in experimental models of...

Patrício, Patrícia; Mateus-Pinheiro, António; Machado-Santos, Ana Rita; Alves, Nuno Dinis Lopes Oliveira; Correia, Joana Sofia Silva; Morais, Mónica

Changes in adult hippocampal cell proliferation and genesis have been largely implicated in depression and antidepressant action, though surprisingly, the underlying cell cycle mechanisms are largely undisclosed. Using both an <i>in vivo</i> unpredictable chronic mild stress (uCMS) rat model of depression and <i>in vitro</i> rat hippocampal-derived neurosphere culture approaches, we aimed to unravel the cell cy...

Date: 2021   |   Origin: RepositóriUM - Universidade do Minho
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