16 documents found, page 1 of 2
Strategies to enhance the response of liver cancer to pharmacological treatments
Marin, Jose J.G.; Macias, Rócio I.R.; Asensio, Maitane; Romero, Marta R.; Temprano, Alvaro G.; Pereira, Olívia R.; Jimenez, Silvia; Mauriz, Jose LuisIn contrast to other types of cancers, there is no available efficient pharmacological treatment to improve the outcomes of patients suffering from major primary liver cancers, i.e., hepatocellular carcinoma and cholangiocarcinoma. This dismal situation is partly due to the existence in these tumors of many different and synergistic mechanisms of resistance, accounting for the lack of response of these patients...
Hepatoprotection of mentha aquatica L., lavandula dentata L. and leonurus cardi...
Pereira, Olívia R.; Macias, Rócio I.R.; Domingues, Maria R.M.; Marin, Jose J.G.; Cardoso, Susana M.The phenolic composition of hydroethanolic extracts of Mentha aquatica L., Lavandula dentata L. and Leonurus cardiaca L., obtained from plants grown under organic cultivation, was determined and their hepatoprotective effects were investigated in vitro . L. cardiaca extract was rich in phenylethenoid glycosides, especially lavandolifolioside (254 ± 36 μg/mg), whereas rosmarinic acid and eriodictyol-O-rutinoside...
Portuguese propolis enriched phenolic extract: reactive oxygen scavenging and c...
Pereira, Olívia R.; Macias, Rócio I.R.; Perez, María J.; Marín, Jose J.G.; Cardoso, Susana M.Propolis, a resinous natural product produced by honeybees, is claimed to have a wide range of beneficial activities for human health which have been attributed to its phenolics. In general, phenolics account for approximately half of propolis weight, although its content and composition can greatly vary with propolis geographical origin. This study aims determining the antioxidant and cytoprotective properties...
Em busca de antioxidantes e agentes hepatoprotetores em plantas
Pereira, Olívia R.; Macias, Rócio I.R.; Perez, María J.; Marín, Jose J.G.; Cardoso, Susana M.As plantas são usadas desde há séculos pelo Homem devido aos seus efeitos benéficos para a saúde, no entanto na maior parte dos casos, nem a composição química nem o mecanismo associado a cada efeito se encontram descritos. De entre as plantas mediterrânicas mais usadas, podem destacar-se espécies das famílias Lamiaceae e Fabaceae, que são reconhecidas fontes de compostos fenólicos. Dado o largo espetro de efei...
Protective effects of phenolic constituents from Cytisus multiflorus, Lamium al...
Pereira, Olívia R.; Macias, Rócio I.R.; Perez, María J.; Marín, Jose J.G.; Cardoso, Susana M.The present study investigated the antioxidant and cytoprotective effects of purified ethanolic extracts of Cytisus multiflorus, Lamium album L. and Thymus citriodorus plants. These extracts showed high antioxidant activity in DPPH and reducing power assays. Using a model of chemical stress induced by potassium dichromate (DK) in human hepatoblastoma HepG2 cells, 50 ug/mL of C. multiflorus, L. album and T. citr...
Antioxidant activities of five Lamiaceae plants
Pereira, Olívia R.; Perez, María J.; Macias, Rócio I.R.; Marín, Jose J.G.; Cardoso, Susana M.In the last decades, oxidative stress has been recognized as a key process in the physiopathology of several diseases. Consequently, the search for new antioxidant compounds, as well as new antioxidant sources, has increased exponentially. The Lamiaceae family encloses many plant species which are potential sources of antioxidant compounds. The present study evaluates the antioxidant activity of phenolic enrich...
Portuguese propolis enriched phenolic extract: reactive oxygen scavenging and c...
Pereira, Olívia R.; Macias, Rócio I.R.; Perez, María J.; Marín, Jose J.G.; Cardoso, Susana M.Propolis, a resinous natural product produced by honeybees, is claimed to have a wide range of beneficial activities for human health which have been attributed to its phenolics. In general, phenolics account for approximately half of propolis weight, although its content and composition can greatly vary with propolis geographical origin. This study aims determining the antioxidant and cytoprotective properties...
Antioxidant activities of five Lamiaceae plants
Pereira, Olívia R.; Perez, María J.; Macias, Rócio I.R.; Marín, Jose J.G.; Cardoso, Susana M.In the last decades, oxidative stress has been recognized as a key process in the physiopathology of several diseases. Consequently, the search for new antioxidant compounds, as well as new antioxidant sources, has increased exponentially. The Lamiaceae family encloses many plant species which are potential sources of antioxidant compounds. The present study evaluates the antioxidant activity of phenolic enrich...
Cytisus multiflorus: source of antioxidant polyphenols
Pereira, Olívia R.; Perez, María J.; Macias, Rócio I.R.; Domingues, Maria R.M.; Silva, Artur; Marín, Jose J.G.; Cardoso, Susana M.The present study investigates the phenolic composition and the antioxidant capacity of an ethanolic extract from flowers of C. multiflorus. As determined by HPLC-DAD, ESI-MSn and NMR combined analysis, this extract was mainly composed of chrysin-7-O-β-D-glycopyranoside, and also contained considerable amounts of rutin, a dihydroxyflavone isomer of chrysin and glycosidic derivatives of luteolin and apigenin. Th...
Antioxidant activities of plants enriched in rosmarinic acid
Pereira, Olívia R.; Perez, María J.; Macias, Rócio I.R.; Domingues, Maria R.M.; Marín, Jose J.G.; Cardoso, Susana M.The present study aims to evaluate the in vitro antioxidant potential of Lavandula dentata and Mentha aquatica plant extracts. For that, ethanolic extracts of the two plants were prepared and their phenolic composition was determined through combined methods of HPLC-DAD and ESI-MS. Moreover, the antioxidant activity of the plant extracts was estimated by: i) evaluation of DPPH scavenging potential and ii) monit...