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Quetiapine treatment reverses depressive-like behavior and reduces DNA methyltr...
Ignácio, Zuleide M.; Réus, Gislaine Z.; Abelaira, Helena M.; Maciel, Amanda L.; Moura, Airam B. de; Matos, Danyela; Demo, Júlia P.Stress in early life has been appointed as an important phenomenon in the onset of depression and poor response to treatment with classical antidepressants. Furthermore, childhood trauma triggers epigenetic changes, which are associated with the pathophysiology of major depressive disorder (MDD). Treat- ment with atypical antipsychotics such as quetiapine, exerts therapeutic effect for MDD patients and induces ...
Date: 2017
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Origin: Oasisbr