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Errors in protein synthesis increase the level of saturated fatty acids and aff...
Araújo, A; Melo, T; Maciel, E; Pereira, C; Morais, C; Santinha, D; Tavares, J; Oliveira, H; Jurado, A; Costa, V; Domingues, P; Domingues, M; Santos, MThe occurrence of protein synthesis errors (mistranslation) above the typical mean mistranslation level of 10−4 is mostly deleterious to yeast, zebrafish and mammal cells. Previous yeast studies have shown that mistranslation affects fitness and deregulates genes related to lipid metabolism, but there is no experimental proof that such errors alter yeast lipid profiles. We engineered yeast strains to misincorpo...
Date: 2018
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Origin: Repositório Aberto da Universidade do Porto