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Neuromodulation of acid-sensitive ion channels (ASICs) and anti-inflammatory po...

Liberato,Hortência Ribeiro; Maciel, Jéssica Bezerra; Silva, Antônio Wlisses Da; Bezerra, Maria Eduarda Uchoa; Brito, Luana San De Oliveira

The xanthone lichenxanthone did not show toxic effects (LC50>1.0 mg/mL). lichenxanthone prevented nociceptive behavior induced by acidic saline, and its analgesic effect was blocked by amiloride, highlighting the involvement of neuromodulation of acid-sensitive ion channels (ASICs). In the analysis of anti-inflammatory activity, concentrations of 0.1 and 0.5 mg/mL of lichenxanthone reduced the edema induced by ...

Date: 2024   |   Origin: RepositóriUM - Universidade do Minho
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