6 documents found, page 1 of 1
Evaluation of thyroid nodules in the Brazilian Public Health Care System, Suppl...
Goulart,Ana Paula Figueiredo Engler; Batista,Eduardo Ruas Martins; Figueira,Marcos Gomes; Magalhães,Patrícia Künzle Ribeiro; Maciel,Léa Maria ZaniniABSTRACT Objective: To obtain data about the evaluation of thyroid nodules (TNs) in the northeastern of the State of São Paulo, compared by health care type, and measure the performance of cytology as a screening test for thyroid cancer (TC). Subjects and methods: We collected data of 597 patients treated in the Brazilian public health care system (SUS), supplementary health (SH) and in private health system (P...
The first five-year evaluation of cystic fibrosis neonatal screening program in...
Maciel,Léa Maria Zanini; Magalhães,Patrícia Künzle Ribeiro; Ciampo,Ieda Regina Lopes Del; Sousa,Maria Luísa Barato de; Fernandes,Maria Inez MachadoThe Hospital of the Ribeirão Preto Medical School, University of São Paulo is one of the three screening centers in São Paulo State, Brazil, and has included a test for cystic fibrosis (CF) since February 6, 2010, by a court order. We evaluated the first five years of this CF-newborn screening program. The original immunoreactive trypsinogen (IRT)/IRT screening protocol was adopted in Brazil. A total of 173,571...
Preoperative detection of TERT promoter and BRAFV600E mutations in papillary th...
Giorgenon,Tatiana Marina Vieira; Carrijo,Fabiane Tavares; Arruda,Maurício Alamos; Cerqueira,Taíse Lima Oliveira; Barreto,Haiara RamosABSTRACT Objectives: This observational study analyzed telomerase reverse transcriptase (pTERT) mutations in 45 fine-needle aspiration (FNA) specimens obtained from thyroid nodules followed by postoperatively confirmation of papillary thyroid cancer (PTC) diagnosis, examining their relationship with clinicopathologic aspects and the BRAFV600E mutation. Subjects and methods: Clinical information was collected fr...
Effects of drying and storage conditions on the stability of TSH in blood spots
Magalhães,Patrícia Künzle Ribeiro; Miranda,Carlos Henrique; Vilar,Fernando Crivelenti; Schmidt,André; Bittar,Roberta RodriguesABSTRACT Objective To evaluate the influence of sample drying and storage temperature on TSH stability in neonatal screening. Subjects and methods Blood samples from 29 adult volunteers as a surrogate for neonatal blood (10 with normal TSH, 9 with overt hypothyroid and 10 with subclinical hypothyroidism) were spotted on filter paper and dried at 22°C or 35°C for 3 hours. The samples were then stored at 22°C, -4...
Medullary thyroid carcinoma – Adverse events during systemic treatment: risk-be...
Maciel,Léa Maria Zanini; Magalhães,Patrícia Künzle RibeiroABSTRACT Medullary thyroid carcinoma (MTC) is a rare neuroendocrine tumor originating from parafollicular C cells of the thyroid and associated with mutations in the proto-oncogene REarranged during Transfection (RET). The prognosis of MTC depends on clinical stage, with a 95.6% 10-year survival rate among patients with localized disease and 40% among patients with advanced disease. Standard chemotherapy and ra...
Programa de Triagem Neonatal do Hospital das Clínicas da Faculdade de Medicina ...
Magalhães,Patrícia Künzle Ribeiro; Turcato,Marlene de Fátima; Angulo,Ivan de Lucena; Maciel,Léa Maria ZaniniO Programa de Triagem Neonatal do Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Brasil, instituído em 1994 diagnosticou, até 2005, 76 crianças com hipotireoidismo congênito, 10 com fenilcetonúria e 25 com hemoglobinopatias, o que representou uma incidência de 1:2.595, 1:19.409, 1:4.120, respectivamente. Foram diagnosticadas 2.747 crianças com traço falciforme (1:37...