4 documents found, page 1 of 1
Lung Cancer Screening: Low-Dose Thoracic Computed Tomography Performed in a Hig...
Moura Cabral, Sara; Abreu, Inês; Madama, Daniela; Estevão, Amélia; Cordeiro, Eugénio; Pimentel, João; Miranda, Nuno; Ferreira, António JorgeIntroduction: The Urgeiriça mines were once the main uranium producer in Portugal. The aim of this study was to estimate the benefit of low-dose chest computed tomography (LDCT) for lung cancer screening in former miners that were considered as being at high-risk.Methods: A subgroup of former miners of the Uranium National Company exposed to uranium and with a smoking load greater than 20 pack-years, agreed to ...
Metabolomic Profiling in Lung Cancer: A Systematic Review
Madama, Daniela; Martins, Rosana; Pires, Ana S.; Botelho, Maria F.; Alves, Marco G.; Abrantes, Ana M.; Cordeiro, Carlos R.Lung cancer continues to be a significant burden worldwide and remains the leading cause of cancer-associated mortality. Two considerable challenges posed by this disease are the diagnosis of 61% of patients in advanced stages and the reduced five-year survival rate of around 4%. Noninvasively collected samples are gaining significant interest as new areas of knowledge are being sought and opened up. Metabolomi...
Amiloidose Pulmonar: Um Desafio Diagnóstico
Alves, Ana; Alfaro, Tiago M.; Madama, Daniela; Freitas, Sara; Cordeiro, Carlos Robalo; Gamboa, FernandaA amiloidose caracteriza-se pela deposição extracelular de substância amilóide em diferentes órgãos e tecidos. O atingimento pulmonar é raro e pode acontecer de forma isolada ou associado a doença sistémica. Descrevem-se dois casos clínicos. Caso 1: Mulher de 71 anos, com antecedentes de bronquiectasias e síndrome de Sjögren, que referia anorexia, emagrecimento e tosse produtiva. O estudo incluiu uma biópsia pu...
Pulmonary Amyloidosis: A Diagnostic Challenge
Alves, Ana; Alfaro, Tiago M.; Madama, Daniela; Freitas, Sara; Robalo-Cordeiro, Carlos; Gamboa, FernandaAmyloidosis is characterized by amyloid extracellular deposition in organs and tissues. Pulmonary involvement is a rare manifestation of the disease and it can be focal or as part of systemic amyloidosis. We report two cases. Case 1: 71 year-old female with bronchiectasis and Sjogren’s syndrome, who complained of anorexia, weight loss and a productive cough. The diagnostic study included a surgical lung biopsy ...