24 documents found, page 1 of 3
Attention-Deficit/Hyperactivity Disorder Animal Model Presents Retinal Alterati...
Sanches, Eliane S.; Boia, Raquel; Leitão, Ricardo A.; Madeira, Maria H.; Fontes-Ribeiro, Carlos A.; Ambrósio, António Francisco; Fernandes, RosaAttention-Deficit/Hyperactivity Disorder (ADHD) is one of the most prevalent neurodevelopmental disorders. Interestingly, children with ADHD seem to experience more ophthalmologic abnormalities, and the impact of methylphenidate (MPH) use on retinal physiology remains unclear. Thus, we aimed to unravel the retina's structural, functional, and cellular alterations and the impact of MPH in ADHD versus the control...
Characterisation of progression of macular oedema in the initial stages of diab...
Lobo, Conceição; Santos, Torcato; Marques, Inês; Madeira, Maria H.; Santos, Ana Rita; Figueira, João; Cunha-Vaz, JoséBACKGROUND/OBJECTIVES: To characterise the prevalence and three-year progression of centre-involving diabetic macular oedema (CI-DMO) in minimal to moderate non-proliferative diabetic retinopathy, using optical coherence tomography (OCT) and measurements of retinal fluid using tissue optical reflectivity ratios (OCT-Leakage). METHODS/METHODS: Seventy-four eyes from 74 patients were followed in a 3-year prospect...
Characterisation of progression of macular oedema in the initial stages of diab...
Lobo, Conceição; Santos, Torcato; Marques, Inês P.; Madeira, Maria H.; Santos, Ana Rita; Figueira, João; Cunha-Vaz, JoséTo characterise the prevalence and three-year progression of centre-involving diabetic macular oedema (CI-DMO) in minimal to moderate non-proliferative diabetic retinopathy, using optical coherence tomography (OCT) and measurements of retinal fluid using tissue optical reflectivity ratios (OCT-Leakage). Seventy-four eyes from 74 patients were followed in a 3-year prospective longitudinal observational cohort of...
Characterization of One-Year Progression of Risk Phenotypes of Diabetic Retinop...
Ribeiro, Luísa; Marques, Inês P.; Coimbra, Rita; Santos, Torcato; Madeira, Maria H.; Santos, Ana Rita; Barreto, Patrícia Susana Correia LopesIntroduction: We characterized the progression of different diabetic retinopathy (DR) phenotypes in type 2 diabetes (T2D). Methods: A prospective longitudinal cohort study (CORDIS, NCT03696810) was conducted with three visits (baseline, 6 months, and 1 year). Demographic and systemic data included age, sex, diabetes duration, lipid profile, and hemoglobin A1c (HbA1c). Ophthalmological examinations included best...
Swept-source OCTA quantification of capillary closure predicts ETDRS severity s...
Santos, Torcato; Warren, Lewis H.; Santos, Ana Rita B. M.; Marques, Inês Pereira; Kubach, Sophie; Mendes, Luís G.; Sisternes, Luís de; Madeira, Maria H.To test whether a single or composite set of parameters evaluated with optical coherence tomography angiography (OCTA), representing retinal capillary closure, can predict non-proliferative diabetic retinopathy (NPDR) staging according to the gold standard ETDRS grading scheme. 105 patients with diabetes, either without retinopathy or with different degrees of retinopathy (NPDR up to ETDRS grade 53), were prosp...
Characterization of one-year progression of risk phenotypes of diabetic retinop...
Ribeiro, Luísa; Marques, Inês P.; Coimbra, Rita; Santos, Torcato; Madeira, Maria H.; Santos, Ana Rita; Barreto, Patrícia; Lobo, ConceiçãoWe characterized the progression of different diabetic retinopathy (DR) phenotypes in type 2 diabetes (T2D). A prospective longitudinal cohort study (CORDIS, NCT03696810) was conducted with three visits (baseline, 6 months, and 1 year). Demographic and systemic data included age, sex, diabetes duration, lipid profile, and hemoglobin A1c (HbA1c). Ophthalmological examinations included best-corrected visual acuit...
Association between neurodegeneration and macular perfusion in the progression ...
Marques, Inês P.; Ferreira, Sónia; Santos, Torcato; Madeira, Maria H.; Santos, Ana Rita; Mendes, Luís; Lobo, Conceição; Cunha-Vaz, JoséThe aim of this study was to explore the relation between retinal neurodegenerative changes and vessel closure (VC) in individuals with nonproliferative diabetic retinopathy (NPDR) in a follow-up period of 3 years. This is a 3-year prospective longitudinal study with four annual visits. This study involved 74 individuals with type 2 diabetes, NPDR, and Early Treatment Diabetic Retinopathy Study grades from 10 t...
Retinal Neurodegeneration in Different Risk Phenotypes of Diabetic Retinal Disease
Madeira, Maria H.; Marques, Inês P.; Ferreira, Sónia; Tavares, Diana; Santos, Torcato; Santos, Ana Rita; Figueira, João; Lobo, ConceiçãoDiabetic retinopathy (DR) has been considered a microvascular disease, but it has become evident that neurodegeneration also plays a key role in this complex pathology. Indeed, this complexity is reflected in its progression which occurs at different rates in different type 2 diabetic (T2D) individuals. Based on this concept, our group has identified three DR progression phenotypes that might reflect the interi...
Microaneurysm Turnover in Mild Non-Proliferative Diabetic Retinopathy is Associ...
Santos, Ana Rita; Mendes, Luís; Madeira, Maria H.; Marques, Inês P.; Tavares, Diana; Figueira, João; Lobo, Conceição; Cunha-Vaz, JoséBackground: Analysis of retinal microaneurysm turnover (MAT) has been previously shown to contribute to the identification of eyes at risk of developing clinically significant complications associated with diabetic retinopathy (DR). We propose to further characterize MAT as a predictive biomarker of DR progression and development of vision-threatening complications. Methods: 212 individuals with type 2 diabetes...
Optical Coherence Tomography Angiography Metrics Monitor Severity Progression o...
Marques, Inês P.; Kubach, Sophie; Santos, Torcato; Mendes, Luís; Madeira, Maria H.; de Sisternes, Luis; Tavares, Diana; Santos, Ana Rita; Lewis, WarrenTo examine retinal vessel closure metrics and neurodegenerative changes occurring in the initial stages of nonproliferative diabetic retinopathy (NPDR) and severity progression in a three-year period. Methods: Three-year prospective longitudinal observational cohort of individuals with type 2 diabetes (T2D), one eye per person, using spectral domain-optical coherence tomography (SD-OCT) and OCT-Angiography (OCT...