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IP1867B suppresses the insulin-like growth factor 1 receptor (IGF1R) ablating e...
Mihajluk, K.; Simms, C.; Reay, M.; Madureira, Patricia A; Howarth, A.; Murray, P.; Nasser, S.; Duckworth, C. A.; Pritchard, D. M.; Pilkington, G. J.High grade gliomas (HGGs) are aggressive primary brain tumours with local invasive growth and poor clinical prognosis. Clinical outcome is compounded by resistance to standard and novel therapeutics. We have evaluated reformulated aspirin (IP1867B) alone and in combination with conventional and novel anti-aHGG agents. We show that recent biopsy-derived aHGG models were highly resistant to conventional therapeut...
Date: 2019
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Origin: Sapientia - Universidade do Algarve