8 documents found, page 1 of 1

Practical Guidance on the Detection of NTRK Fusions in Sarcomas: Current Status...

Sarcomas are a rare and heterogeneous group of mesenchymal malignant tumors and account for approximately 1% of all adult cancers and around 20% of all pediatric solid tumors in Europe. Technology advances have enabled a more accurate and efficient characterization of the molecular mechanisms underlying the pathogenesis of sarcoma subtypes and revealed novel and unexpected therapeutic targets with prognostic/pr...

Adjuvant Chemotherapy De-Escalation with Genomic Assay Protocol in Patients wit...

Introduction: Genomic assays are useful tools for tailoring adjuvant treatment in early breast cancer. We aimed to analyse the role of an institutional protocol of a genomic assay for chemotherapy de-escalation.Methods: Prospective cohort study of all consecutive women diagnosed with hormone receptor-positive and human epidermal growth factor receptor 2-negative early breast cancer, tested with the 21-gene Recu...

Light Higgs searches in tt¯ ϕ production at the LHC

In this paper we propose a new reconstruction method to explore the low mass region in the associated production of top-quark pairs (tt¯) with a generic scalar boson (ϕ) at the LHC. The new method of mass reconstruction shows an improved resolution of at least a factor of two in the low mass region when compared to previous methods, without the loss of sensitivity of previous analyses. It turns out that it also...

Light Higgs searches in t(t)over-bar phi production at the LHC

In this paper we propose a new reconstruction method to explore the low mass region in the associated production of top-quark pairs (t (t) over bar) with a generic scalar boson (phi) at the LHC. The new method of mass reconstruction shows an improved resolution of at least a factor of two in the low mass region when compared to previous methods, without the loss of sensitivity of previous analyses. It turns out...

The Role of the $t{\bar t}h$ Rest Frame in Direct Top-Quark Yukawa Coupling Mea...

This paper studies new possibilities to directly measure a hypothetical $CP$-odd (pseudoscalar) component in the top-quark Yukawa coupling. In particular, the role of the $t{\bar t} h$ center-of-mass rest frame in the associated production of a top pair and a $h$ boson at the LHC is explored. The $h$ boson is assumed to have both a $CP$-even (scalar) and a $CP$-odd coupling to the top quark. The relative streng...

Using a cancer registry to capture signals of adverse events following immune a...

Background Toxicity of oncology treatments in real-life patients is frequently disregarded and hence underreported. Objective To characterize adverse events (AEs) of immunotherapy and targeted therapy reported in patients with locally advanced or metastatic melanoma. Setting District Hospital for Cancer treatment (Instituto Português de Oncologia de Lisboa Francisco Gentil). Method A retrospective cohort of mel...

Recomendações para a preservação do potencial reprodutivo no doente oncológico

Objective: To provide updated information about the preservation of reproductive potential in adult cancer based on the available evidence. Methods: A review of literature published after 2006 was performed using the Medline and PubMed. The evidence was analyzed by specialists from several medical societies; and reflected upon their onclinical practice. After discussion on several working groups, a series of re...

Recomendações para a preservação do potencial reprodutivo no doente oncológico.