7 documents found, page 1 of 1
MAVS expression in alveolar macrophages is essential for host resistance agains...
Wang, Xi; Cunha, Cristina; Grau, Madeleine S.; Robertson, Shelly J.; Lacerda, João; Campos, António; Lagrou, Katrien; Maertens, Johan; Best, Sonja M.Our recent data demonstrate a critical role of the RIG-I-like receptor family in regulating antifungal immunity against Aspergillus fumigatus in a murine model. However, the importance of this pathway in humans and the cell types that use this innate immune receptor family to detect A. fumigatus remain unresolved. In this study, using patients who underwent hematopoietic stem cell transplantation, we demonstrat...
Genetic variation in PFKFB3 impairs antifungal immunometabolic responses and pr...
Gonçalves, Samuel M.; Antunes, Daniela; Leite, Luis; Mercier, Toine; Horst, Rob Ter; Vieira, Joana; Espada, Eduardo; Pinho Vaz, Carlos; Branca, RosaActivation of immune cells in response to fungal infection involves the reprogramming of their cellular metabolism to support antimicrobial effector functions. Although metabolic pathways such as glycolysis are known to represent critical regulatory nodes in antifungal immunity, it remains undetermined whether these are differentially regulated at the interindividual level. In this study, we identify a key role...
Serum amyloid P component is an essential element of resistance against Aspergi...
Doni, Andrea; Parente, Raffaella; Laface, Ilaria; Magrini, Elena; Cunha, Cristina; Colombo, Federico Simone; Lacerda, João; Campos, AntónioSerum amyloid P component (SAP, also known as Pentraxin 2; APCS gene) is a component of the humoral arm of innate immunity involved in resistance to bacterial infection and regulation of tissue remodeling. Here we investigate the role of SAP in antifungal resistance. Apcs-/- mice show enhanced susceptibility to A. fumigatus infection. Murine and human SAP bound conidia, activate the complement cascade and enhan...
Invasive pulmonary aspergillosis treatment duration in haematology patients in ...
Lanternier, Fanny; Seidel, Danila; Pagano, Livio; Styczynski, Jan; Mikulska, Malgorzata; Pulcini, Celine; Maertens, Johan; Munoz, PatriciaInvasive pulmonary aspergillosis (IPA) optimal duration of antifungal treatment is not known. In a joint effort, four international scientific societies/groups performed a survey to capture current practices in European haematology centres regarding management of IPA. We conducted a cross-sectional internet-based questionnaire survey in 2017 to assess practices in sixteen European countries concerning IPA manag...
Phagosomal removal of fungal melanin reprograms macrophage metabolism to promot...
Gonçalves, Samuel M.; Duarte-Oliveira, Cláudio; Campos, Cláudia F.; Aimanianda, Vishukumar; ter Horst, Rob; Leite, Luis; Mercier, ToineIn response to infection, macrophages adapt their metabolism rapidly to enhance glycolysis and fuel specialized antimicrobial effector functions. Here we show that fungal melanin is an essential molecule required for the metabolic rewiring of macrophages during infection with the fungal pathogen Aspergillus fumigatus. Using pharmacological and genetic tools, we reveal a molecular link between calcium sequestrat...
Genetic deficiency of NOD2 confers resistance to invasive aspergillosis
Gresnigt, Mark S.; Cunha, Cristina; Jaeger, Martin; Gonçalves, Samuel Martins; Malireddi, R. K. Subbarao; Ammerdorffer, Anne; Lubbers, RosalieInvasive aspergillosis (IA) is a severe infection that can occur in severely immunocompromised patients. Efficient immune recognition of Aspergillus is crucial to protect against infection, and previous studies suggested a role for NOD2 in this process. However, thorough investigation of the impact of NOD2 on susceptibility to aspergillosis is lacking. Common genetic variations in NOD2 has been associated with ...
Genetic deficiency of NOD2 confers resistance to invasive aspergillosis
Gresnigt, Mark S.; Cunha, Cristina; Jaeger, Martin; Gonçalves, Samuel M.; Malireddi, R. K. Subbarao; Ammerdorffer, Anne; Lubbers, RosalieInvasive aspergillosis (IA) is a severe infection that can occur in severely immunocompromised patients. Efficient immune recognition of Aspergillus is crucial to protect against infection, and previous studies suggested a role for NOD2 in this process. However, thorough investigation of the impact of NOD2 on susceptibility to aspergillosis is lacking. Common genetic variations in NOD2 has been associated with ...