15 documents found, page 1 of 2
Gait speed in clinical and daily living assessments in Parkinson’s disease pati...
Atrsaei, Arash; Corrà, Marta; Dadashi, Farzin; Vila Cha, Nuno; Maia, Luis; Mariani, Benoit; Maetzler, Walter; Aminian, KamiarGait speed often referred as the sixth vital sign is the most powerful biomarker of mobility. While a clinical setting allows the estimation of gait speed under controlled conditions that present functional capacity, gait speed in real-life conditions provides the actual performance of the patient. The goal of this study was to investigate objectively under what conditions during daily activities, patients perf...
Motor, cognitive and mobility deficits in 1000 geriatric patients: protocol of ...
Geritz, Johanna; Maetzold, Sara; Steffen, Maren; Pilotto, Andrea; Corrà, Marta; Moscovich, Mariana; Rizzetti, Maria C; Borroni, BarbaraBackground: Motor and cognitive deficits and consequently mobility problems are common in geriatric patients. The currently available methods for diagnosis and for the evaluation of treatment in this vulnerable cohort are limited. The aims of the ComOn (COgnitive and Motor interactions in the Older populatioN) study are (i) to define quantitative markers with clinical relevance for motor and cognitive deficits,...
Wearable Health Technology to Quantify the Functional Impact of Peripheral Neur...
Corrà, Marta; Warmerdam, Elke; Vila-Chã, Nuno; Maetzler, Walter; Maia, LuisThe occurrence of peripheral neuropathy (PNP) is often observed in Parkinson's disease (PD) patients with a prevalence up to 55%, leading to more prominent functional deficits. Motor assessment with mobile health technologies allows high sensitivity and accuracy and is widely adopted in PD, but scarcely used for PNP assessments. This review provides a comprehensive overview of the methodologies and the most rel...
Motor, cognitive and mobility deficits in 1000 geriatric patients : protocol of...
Geritz, Johanna; Maetzold, Sara; Steffen, Maren; Pilotto, Andrea; Corrà, Marta F.; Moscovich, Mariana; Rizzetti, Maria C.; Borroni, BarbaraBackground: Motor and cognitive deficits and consequently mobility problems are common in geriatric patients. The currently available methods for diagnosis and for the evaluation of treatment in this vulnerable cohort are limited. The aims of the ComOn (COgnitive and Motor interactions in the Older populatioN) study are (i) to define quantitative markers with clinical relevance for motor and cognitive deficits,...
What is functional mobility applied to Parkinson’s disease?
Bouça-Machado, Raquel; Maetzler, Walter; Ferreira, Joaquim JAlthough yet poorly defined and often misused, the concept of functional mobility has been used in research studies as a more global and ecological outcome of patients’ health status. Functional mobility is a person’s physiological ability to move independently and safely in a variety of environments in order to accomplish functional activities or tasks and to participate in the activities of daily living, at h...
TBK1 mutation spectrum in an extended European patient cohort with frontotempor...
van der Zee, Julie; Gijselinck, Ilse; Van Mossevelde, Sara; Perrone, Federica; Dillen, Lubina; Heeman, Bavo; Bäumer, Veerle; Engelborghs, SebastiaanWe investigated the mutation spectrum of the TANK-Binding Kinase 1 (TBK1) gene and its associated phenotypic spectrum by exonic resequencing of TBK1 in a cohort of 2,538 patients with frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS), or FTD plus ALS, ascertained within the European Early-Onset Dementia Consortium. We assessed pathogenicity of predicted protein-truncating mutations by measuring...
Algorithm for turning detection and analysis validated under home-like conditio...
Pham, Minh H.; Elshehabi, Morad; Haertner, Linda; Heger, Tanja; Hobert, Markus A.; Faber, Gert S.; Salkovic, Dina; Ferreira, Joaquim J; Berg, DanielaIntroduction: Aging and age-associated disorders such as Parkinson's disease (PD) are often associated with turning difficulties, which can lead to falls and fractures. Valid assessment of turning and turning deficits specifically in non-standardized environments may foster specific treatment and prevention of consequences. Methods: Relative orientation, obtained from 3D-accelerometer and 3D-gyroscope data of a...
Validation of a step detection algorithm during straight walking and turning in...
Pham, Minh H.; Elshehabi, Morad; Haertner, Linda; Del Din, Silvia; Srulijes, Karin; Heger, Tanja; Synofzik, Matthis; Hobert, Markus A.; Faber, Gert S.Introduction: Inertial measurement units (IMUs) positioned on various body locations allow detailed gait analysis even under unconstrained conditions. From a medical perspective, the assessment of vulnerable populations is of particular relevance, especially in the daily-life environment. Gait analysis algorithms need thorough validation, as many chronic diseases show specific and even unique gait patterns. The...
New methods for the assessment of Parkinson’s Disease (2005 to 2015): a systema...
Sánchez-Ferro, Alvaro; Elshehabi, Morad; Godinho, Catarina; Salkovic, Dina; Hobert, Markus A.; Domingos, Josefa; van Uem, Janet MT."BACKGROUND: The past decade has witnessed a highly dynamic and growing expansion of novel methods aimed at improving the assessment of Parkinson's disease with technology (NAM-PD) in laboratory, clinical, and home environments. However, the current state of NAM-PD regarding their maturity, feasibility, and usefulness in assessing the main PD features has not been systematically evaluated. METHODS: A systematic...
A systematic review of the characteristics and validity of monitoring technolog...
Godinho, Catarina; Domingos, Josefa; Cunha, Guilherme; Santos, Ana T.; Fernandes, Ricardo; Abreu, Daisy; Gonçalves, Nilza; Matthews, Helen; Isaacs, Tom"Background: There is growing interest in having objective assessment of health-related outcomes using technology-based devices that provide unbiased measurements which can be used in clinical practice and scientific research. Many studies have investigated the clinical manifestations of Parkinson’s disease using such devices. However, clinimetric properties and clinical validation vary among the different devi...