2 documents found, page 1 of 1
Novel tacrine-benzofuran hybrids as potential multi-target drug candidates for ...
Fancellu, Gaia; Chand, Karam; Tomás, Daniel; Orlandini, Elisabetta; Piemontese, Luca; Silva, Diana F.; Cardoso, Sandra M.; Chaves, SílviaPursuing the widespread interest on multi-target drugs to combat Alzheimer´s disease (AD), a new series of hybrids was designed and developed based on the repositioning of the well-known acetylcholinesterase (AChE) inhibitor, tacrine (TAC), by its coupling to benzofuran (BF) derivatives. The BF framework aims to endow the conjugate molecules with ability for inhibition of AChE (bimodal way) and of amyloid-beta ...
New Multitarget Hybrids Bearing Tacrine and Phenylbenzothiazole Motifs as Poten...
Rajeshwari, Rajeshwari; Chand, Karam; Candeias, Emanuel; Cardoso, Sandra M.; Chaves, Sílvia; Santos, M. AméliaResearch on neurodegenerative brain disorders, namely the age-dependent Alzheimer's disease (AD), has been intensified in the last decade due to the absence of a cure and the recognized increasing of life expectancy for populations. To address the multifactorial nature and complexity of AD, a multi-target-directed ligand approach was herein employed, by designing a set of six selected hybrids (14⁻19) that combi...