11 documents found, page 1 of 2
BRAF V600E Mutation and 9p21: CDKN2A/B and MTAP Co-Deletions - Markers in the C...
Frazão, L; Martins, MC; Nunes, VM; Pimentel, J; Faria, C; Miguéns, J; Sagarribay, A; Matos, M; Salgado, D; Nunes, S; Mafra, M; Roque, LGenetic alterations in pediatric primary brain tumors can be used as diagnostic and prognostic markers and are the basis for the development of new target therapies that, ideally, would be associated with lower mortality and morbidity. This study evaluates the incidence and interplay of the presence of BRAF V600E mutation and chromosomal 9p21 deletions in a series of 100 pediatric gliomas, aiming to determine t...
Lesão Incomum da Base do Crânio: Hemangiopericitoma da Fossa Craniana Média
Bilreiro, C; Coiteiro, D; Mafra, M; Borges, AMeningioma is the most common intracranial tumor affecting the skull base and the diagnosis is usually straightforward on imaging studies. However, other lesions may present similar findings. A 60 year-old-man presented with memory loss and behavioral changes. Computed Tomography (CT) and Magnetic Resonance (MR) imaging disclosed an extra-axial, dural-based lesion of the middle cranial fossa. The lesion was str...
Simultaneous Supratentorial and Infratentorial Pilocytic Astrocytomas in an Adu...
Forte, D; Nabais, A; Pontinha, C; Mafra, M; Mateus, LBACKGROUND: Neurofibromatosis type 1 (NF1) has been identified as a predisposing factor in the development of pilocytic astrocytoma (PA), a common benign central nervous system tumor. Although this is a common association, simultaneous development of multiple lesions is an infrequent finding, especially in nonoptic and hypothalamic locations. CASE DESCRIPTION: A 41-year-old female patient with NF1 and uncontrol...
Nasal Lobular Capillary Hemangioma as a Complication after an Endoscopic Transs...
Forte, Da; Irañeta, A; Nabais, A; Figueiredo, A; Mafra, M; Gonçalves, VBackground Lobular capillary hemangioma is a rare benign tumor, most frequently located in the head or neck region, the nasal cavity being uncommonly affected. Its etiopathogenesis is not fully established, although traumatic and hormonal factors have been implied. Case Description A 50-year-old female patient underwent an uneventful endoscopic transsphenoidal removal of a pituitary cystic macroadenoma at our i...
Right Cardiac Intracavitary Metastases from a Primary Intracranial Myxofibrosar...
Alpuim Costa, D; Barata, P; Gouveia, E; Mafra, MPrimary intracranial myxofibrosarcoma is exceedingly rare, with less than 10 cases published. We present a case of a 23-year-old man with previous history of a primary low grade myxofibrosarcoma of the left parietal-occipital convexity resected in March 1999. He subsequently underwent several interventions for multiple local recurrent disease until March 2004. At that time, complete remission was documented. Ab...
Aggressive Pituitary Lesion with a Remarkably High Ki-67
Marques, P; Mafra, M; Calado, C; Martins, A; Monteiro, J; Leite, VOs raros tumores pituitários agressivos são chamados carcinomas quando são detectadas metástases, sejam sistêmicas e/ou em sistema nervoso central. Alguns casos estão associados com superprodução de hormônio, mas a maioria é diagnosticada em função dos sintomas locais. Essas neoplasias são geralmente refratárias aos tratamentos atuais. Uma mulher com 51 anos de idade apresentou dor de cabeça de início súbito, p...
IgG4-Related Hashimoto's Thyroiditis - A New Variant of a Well Known Disease
Vara Luiz, H; Gonçalves, D; Nunes da Silva, T; Nascimento, I; Ribeiro, A; Mafra, M; Manita, I; Portugal, JHashimoto's thyroiditis (HT) has been characterized for many years as a well-defined clinicopathologic entity, but is now considered a heterogeneous disease. IgG4-related HT is a new subtype characterized by thyroid inflammation rich in IgG4-positive plasma cells and marked fibrosis. It may be part of the systemic IgG4-related disease. We report a case of a 56-year-old Portuguese man who presented with a one-mo...
Brachial Plexus Morphology and Vascular Supply in the Wistar Rat
Almeida, MA; Casal, D; Mafra, M; Mascarenhas-Lemos, L; Martins-Ferreira, J; Ferraz-Oliveira, M; Amarante, J; Goyri-O'Neill, JIntroduction: The rat is probably the animal species most widely used in experimental studies on nerve repair. The aim of this work was to contribute to a better understanding of the morphology and blood supply of the rat brachial plexus. Material and Methods: Thirty adult rats were studied regarding brachial plexus morphology and blood supply. Intravascular injection and dissection under an operating microscop...
A 63-Year-Old Woman Presenting with a Synovial Sarcoma of the Hand: a Case Report
Casal, D; Ribeiro, AI; Mafra, M; Azeda, C; Mavioso, C; Mendes, MM; Mouzinho, MMINTRODUCTION: Synovial sarcoma is a high-grade, soft-tissue sarcoma that most frequently is located in the vicinity of joints, tendons or bursae, although it can also be found in extra-articular locations. Most patients with synovial sarcoma of the hand are young and have a poor prognosis, as these tumors are locally aggressive and are associated with a relatively high metastasis rate. According to the literatu...
Primary lymphoma of the central nervous system in a patient with AIDS.
Bau, J; Teotónio, R; Pacheco, M H; Mafra, M; Coutinho, FThe increasing incidence of primary brain lymphoma appears to be real in immunologically normal people. However, lymphoma of the central nervous system has a much higher incidence in patients with immune deficient status as in renal and cardiac transplants, patients with IgA deficiency, or Wiskott-Aldrich syndrome. Thus, the increased predisposition of AIDS patients to brain lymphoma is not surprising, this bei...