50 documents found, page 1 of 5
Breast cancer patient-reported outcomes on level 1 and level 2 oncoplastic proc...
Pinto, CA; Peleteiro, B; Pinto, CS; Osório, F; Costa, S; Magalhães, A; Mora, H; Amaral, J; Gonçalves, D; Fougo, JLPurpose In breast cancer management not only mortality and surgical morbidity measurements are important but also patient satisfaction indexes. The authors evaluated the satisfaction and health-related quality of life (HRQOL) using the breast-conserving therapy (BCT) and breast reduction (BR) modules of BREAST-Q®. Methods This is a cross-sectional study that analyzed breast cancer patients consecutively submitt...
Initial experience with targeted axillary dissection after neoadjuvant therapy ...
Pinto, CS; Peleteiro, B; Pinto, CA; Osório, F; Costa, S; Magalhães, A; Mora, H; Amaral, J; Gonçalves, D; Fougo, JLBackground: Targeted axillary dissection (TAD) combines sentinel node biopsy (SNB) with the removal of the previously marked metastatic node. TAD is a promising concept for axillary restaging in node-positive breast cancer patients with pathological complete response (pCR) to neoadjuvant therapy (NAT). We aimed to evaluate TAD feasibility in this context. Methods: A prospective observational study was conducted...
Erasmus Syndrome: an Underrecognized Entity
Magalhães, A; Moreira, I; Pinheiro, S; Borba, AWe present a case of a 33-year-old male who worked as a plumber and a locksmith. The patient presented with diffuse myalgia and asthenia, skin sclerosis and puffy fingers, Raynaud's phenomenon, exertional dyspnea and erectile dysfunction. The presence of specific autoantibodies enabled the diagnosis of systemic sclerosis. Chest-computed tomography revealed upper lobe consolidation. After extensive evaluation, t...
Mycobacterium tuberculosis infection up-regulates sialyl lewis x expression in ...
Matos, R; Fonseca, KL; Mereiter, S; Maceiras, AR; Gomes, J; Vilaplana, C; Gärtner, F; Rodrigues, P; Reis, CA; Saraiva, M; Magalhães, AGlycans display increasingly recognized roles in pathological contexts, however, their impact in the host-pathogen interplay in many infectious diseases remains largely unknown. This is the case for tuberculosis (TB), one of the ten most fatal diseases worldwide, caused by infection of the bacteria Mycobacterium tuberculosis. We have recently reported that perturbing the core-2 O-glycans biosynthetic pathway in...
Heparan sulfate glycosaminoglycans: (un)expected allies in cancer clinical mana...
Faria-Ramos, I; Poças, J; Marques, C; Santos-Antunes, J; Macedo, G; Reis, CA; Magalhães, AIn an era when cancer glycobiology research is exponentially growing, we are witnessing a progressive translation of the major scientific findings to the clinical practice with the overarching aim of improving cancer patients’ management. Many mechanistic cell biology studies have demonstrated that heparan sulfate (HS) glycosaminoglycans are key molecules responsible for several molecular and biochemical proces...
Astrocyte-derived TNF and glutamate critically modulate microglia activation by...
Canedo, T; Portugal, CC; Socodato, R; Almeida, TO; Terceiro, AF; Bravo, J; Silva, AI; Magalhães, JD; Guerra-Gomes, S; Oliveira, JF; Sousa, NMethamphetamine (Meth) is a powerful illicit psychostimulant, widely used for recreational purposes. Besides disrupting the monoaminergic system and promoting oxidative brain damage, Meth also causes neuroinflammation, contributing to synaptic dysfunction and behavioral deficits. Aberrant activation of microglia, the largest myeloid cell population in the brain, is a common feature in neurological disorders tri...
Heparan Sulfate Biosynthesis and Sulfation Profiles as Modulators of Cancer Sig...
Marques, C; Reis, CA; Vivès, RR; Magalhães, AHeparan Sulfate Proteoglycans (HSPGs) are important cell surface and Extracellular Matrix (ECM) maestros involved in the orchestration of multiple cellular events in physiology and pathology. These glycoconjugates bind to various bioactive proteins via their Heparan Sulfate (HS) chains, but also through the protein backbone, and function as scaffolds for protein-protein interactions, modulating extracellular li...
Adhesion of Helicobacter Species to the Human Gastric Mucosa: A Deep Look Into ...
Matos, R; Amorim, I; Magalhães, A; Haesebrouck, F; Gärtner, F; Reis, CAHelicobacter species infections may be associated with the development of gastric disorders, such as gastritis, peptic ulcers, intestinal metaplasia, dysplasia and gastric carcinoma. Binding of these bacteria to the gastric mucosa occurs through the recognition of specific glycan receptors expressed by the host epithelial cells. This review addresses the state of the art knowledge on these host glycan structure...
Predictors of survival and technical success of bronchoscopic interventions in ...
Freitas, C; Serino, M; Cardoso, C; Saleiro, S; Vaz, AP; Bastos, HN; Morais, A; Magalhães, A; Fernandes, GBackground: Malignant airway obstruction (MAO) leads to quality of life impairment and increased mortality. Interventional bronchoscopy allows airway patency restoring, leading to a better survival. We investigated predictors of survival and successful bronchoscopic intervention among MAO patients. Methods: This observational prospective study enrolled 100 patients who were newly diagnosed with MAO. Survival wa...
The cdh1 c.1901c>t variant: A founder variant in the portuguese population w...
Barbosa-Matos, R; Leal Silva, R; Garrido, L; Aguiar, AC; Garcia-Pelaez, J; André, A; Seixas, S; Sousa, SP; Ferro, L; Vilarinho, L; Gullo, I; Devezas, VHereditary diffuse gastric cancer (HDGC) caused by CDH1 variants predisposes to early-onset diffuse gastric (DGC) and lobular breast cancer (LBC). In Northern Portugal, the unusually high number of HDGC cases in unrelated families carrying the c.1901C>T variant (formerly known as p.A634V) suggested this as a CDH1-founder variant. We aimed to demonstrate that c.1901C>T is a bona fide truncating variant inducing ...