Enquadramento: O uso crónico de opioides compromete a quimiossensibilidade central ao dióxido de carbono (CO₂) e oxigénio (O₂), favorecendo a instabilidade ventilatória e podendo levar à Síndrome de Apneia Central do Sono (SACS) [1]. Descreve-se o caso de uma mulher de 40 anos, fumadora, com índice de massa corporal (IMC) de 38,1 kg/m², em programa de substituição com metadona, referenciada para consulta de Pat...
Diabetes is known to negatively impact the brain, leading to memory loss and attention issues [1], as well as an increased incidence of depression, cognitive impairment, and behavioral changes. Recent studies indicate that angiotensin II AT1 receptor antagonists (ARAs) may reduce depressive symptoms, however, the mechanism of action is not yet fully understood [2]. The aim of the present study was to verify whe...
Este artigo discute se as entidades privadas devem ser encorajadas a participar na resolução de conflitos do quadro das Nações Unidas quando a comunidade global é incapaz ou não tem vontade política de o fazer. Na última década, tem-se desenvolvido um fenómeno, talvez o mais interessante na história da guerra nos últimos tempos: o crescimento de Empresas Militares Privadas (EMPs). São empresas que comercializam...
Estudos mostraram uma associação entre o consumo de alimentos ultraprocessados e um maior risco de Diabetes Tipo 2. A crescente prevalência do diabetes tipo 2 em jovens destaca a importância de entender e abordar os hábitos alimentares desde cedo. Objetivos: Avaliar a relação entre o consumo de alimentos ultraprocessados com o risco de Diabetes Tipo 2. Metodologia: Estudo observacional, transversal realizado nu...
Introdução: Cada vez mais os pais revelam dúvidas, receios e falta de experiência, evidenciando a necessidade sentida pelas grávidas de frequentarem cursos de preparação para a parentalidade, de forma a obterem mais informações sobre a gravidez, a preparação do enxoval, o parto, os cuidados ao recém-nascido e até o envolvimento do pai do bebé e da restante família. Objetivo: Construir e testar a validade de con...
Introduction: Acute kidney injury (AKI) is a frequent complication of community-acquired pneumonia (CAP). Nonetheless, the underlying pathophysiology is not fully understood. Certain factors have shown association with increased risk, but there is still data lacking. The main objective of this study was to identify factors associated with AKI in CAP. Methods: We conducted a retrospective study in patients with ...
This article aims to analyze and interpret five churches designed during the 1950s and 1960s in Angola and Mozambique. They are exemplary works not only in their response to the tropical climate or in the renewal of the space of the sacred in the relationship between art and architecture, but also fundamental in the construction of public space and as equipment for fixing the population. Today, in a post-coloni...
Drug abuse is characterized by a compulsive and persistent drug-seeking behaviour, despite the harmful emotional, physical and social consequences. Our laboratory has previously found that the neuronal-glial crosstalk is critical in relaying the changes caused by acute exposure to psychoactive drugs through neuroimmune mechanisms. We have also reported that microglia can engulf postsynaptic components in the pr...
It is now well-accepted that psychostimulants act on glial cells causing neuroinflammation and adding to the neurotoxic effects of such substances. Neuroinflammation can be described as an inflammatory response, within the CNS, mediated through several cytokines, reactive oxygen species, chemokines and other inflammatory markers. These inflammatory players, in particular cytokines, play important roles. Several...
Microglia, the largest population of brain immune cells, continuously interact with synapses to maintain brain homeostasis. In this study, we use conditional cell-specific gene targeting in mice with multi-omics approaches and demonstrate that the RhoGTPase Rac1 is an essential requirement for microglia to sense and interpret the brain microenvironment. This is crucial for microglia-synapse crosstalk that drive...