8 documents found, page 1 of 1
Fibrin strands in peripheral blood smear: The COVID-19 era
Sousa, S; Magalhães, C; Teixeira, C; Eremina, YO[No abstract available]
Heterogeneous Streptomycin Resistance Level Among Mycobacterium tuberculosis St...
Rocha, DMGC; Magalhães, C; Cá, B; Ramos, A; Carvalho, T; Comas, I; Guimarães, JT; Bastos, HN; Saraiva, M; Osório, NSWidespread and frequent resistance to the second-line tuberculosis (TB) medicine streptomycin, suggests ongoing transmission of low fitness cost streptomycin resistance mutations. To investigate this hypothesis, we studied a cohort of 681 individuals from a TB epidemic in Portugal. Whole-genome sequencing (WGS) analyses were combined with phenotypic growth studies in culture media and in mouse bone marrow deriv...
Mycobacterium tuberculosis associated with severe tuberculosis evades cytosolic...
Sousa, J; Cá, B; Maceiras, AR; Simões-Costa, L; Fonseca, KL; Fernandes, AI; Ramos, A; Carvalho, T; Barros, L; Magalhães, C; Chiner-Oms, Á; Machado, HGenetic diversity of Mycobacterium tuberculosis affects immune responses and clinical outcomes of tuberculosis (TB). However, how bacterial diversity orchestrates immune responses to direct distinct TB severities is unknown. Here we study 681 patients with pulmonary TB and show that M. tuberculosis isolates from cases with mild disease consistently induce robust cytokine responses in macrophages across multiple...
Mycobacterium tuberculosis associated with severe tuberculosis evades cytosolic...
Sousa, J; Cá, B; Maceiras, AR; Simões-Costa, L; Fonseca, KL; Fernandes, AI; Ramos, A; Carvalho, T; Barros, L; Magalhães, C; Chiner-Oms, Á; Machado, HGenetic diversity of Mycobacterium tuberculosis affects immune responses and clinical outcomes of tuberculosis (TB). However, how bacterial diversity orchestrates immune responses to direct distinct TB severities is unknown. Here we study 681 patients with pulmonary TB and show that M. tuberculosis isolates from cases with mild disease consistently induce robust cytokine responses in macrophages across multiple...
A nonribosomal peptide synthase gene driving virulence in Mycobacterium tubercu...
Bhatt, K; Machado, H; Osório, N; Sousa, J; Cardoso, F; Magalhães, C; Chen, B; Chen, M; Kim, J; Singh, A; Ferreira, C; Castro, A; Torrado, E; Jacobs, WNonribosomal peptide synthases produce short peptides in a manner that is distinct from classical mRNA-dependent ribosome-mediated translation. The Mycobacterium tuberculosis genome harbors a nonribosomal peptide synthase gene, nrp, which is part of a gene cluster proposed to be involved in the biosynthesis of isonitrile lipopeptides. Orthologous clusters are found in other slow-growing pathogenic mycobacteria ...
G2P[4] the most prevalent rotavirus genotype in 2007 winter season in an Europe...
Antunes, H; Afonso, A; Iturriza, M; Martinho, I; Ribeiro, C; Rocha, S; Magalhães, C; Carvalho, L; Branca, F; Gray, JBACKGROUND: Recently, a high prevalence of G2P[4] rotavirus (RV) infection was reported from Brazil, and linked with the universal RV vaccination programme that used the G1P[8] live oral RV vaccine. OBJECTIVE: To determine the genotypes of RV co-circulating in a non-vaccinated population, in northern Portugal in the winter season of 2007. STUDY DESIGN: Prospective multicenter study of the genotypes circulating ...
Crise hipercalcémia secundária a hiperparatiroidismo primário durante a gravidez
Branco, MR; Rodrigues, CT; Campos, A; Figueiredo, A; Coucelo, J; Magalhães, C; Santos-Silva, I; Taborda, A; Almeida, MCPrimary hyperparathyroidism is a rare occurrence in pregnancy with significant risks to the mother and the foetus, witch is related to the level of serum calcium. A 41-year-old women, gravida 2, para 1, presented at 22 weeks gestation with nausea, vomiting and mild cognitive dysfunction associated with hypercalcemic crisis. The hypercalcemia was observed to be related to parathyroid hyperplasia that was surgica...
Abnormal NK cell lymphocytosis detected after splenectomy: association with rep...
Granjo, E; Lima, M; Fraga, M; Santos, F; Magalhães, C; Queirós, ML; Moreira, I; Rocha, S; Silva, AS; Rebelo, I; Quintanilha, A; Ribeiro, ML; Candeias, JAbnormal NK cell lymphocytosis detected after splenectomy: association with repeated infections, relapsing neutropenia, and persistent polyclonal B-cell proliferation. Granjo E, Lima M, Fraga M, Santos F, Magalhães C, Queirós ML, Moreira I, Rocha S, Silva AS, Rebelo I, Quintanilha A, Ribeiro ML, Candeias J, Orfão A. Department of Hematology, Hospital S. João, Porto, Portugal. npp46740@mail.telepac.pt Abstract W...