2 documents found, page 1 of 1
Unmoving and uninflamed: characterizing neuroinflammatory dysfunction in the Wi...
Farinha Ferreira, Jorge Miguel; Magalhães, Daniela M; Neuparth-Sottomayor, Mariana; Rafael, H.; Miranda-Lourenço, Catarina; Sebastião, Ana MReductionistic research on depressive disorders has been hampered by the limitations of animal models. Recently, it has been hypothesized that neuroinflammation is a key player in depressive disorders. The Wistar-Kyoto (WKY) rat is an often-used animal model of depression, but no information so far exists on its neuroinflammatory profile. As such, we compared male young adult WKY rats to Wistar (WS) controls, w...
Age-related impact of social isolation in mice: young vs middle-aged
Magalhães, Daniela M; Mampay, Myrthe; Sebastião, Ana M; Sheridan, Graham K.; Valente, Cláudia A.Social isolation is a chronic mild stressor and a significant risk factor for mental health disorders. Herein we explored the impact of social isolation on depression- and anxiety-like behaviours, as well as spatial memory impairments, in middle-aged male mice compared to post-weaning mice. We aimed to quantify and correlate social isolation-induced behaviour discrepancies with changes in hippocampal glial cell...