8 documents found, page 1 of 1
Ibuprofen antifungal activity on both planktonic and biofilm forms of fluconazo...
Sampaio, Letícia S.; Silva, Cecília R. da; Campos, Rosana S.; Nascimento, Francisca Bruna Stefany Aires do; Andrade Neto, João Batista deOver the past few decades, researches have reported an increased incidence of invasive candidiasis and suggested that the majority of infections produced by this pathogen are associated with biofilm growth, which are more resistant to antimicrobial agents than planktonic cells. In addition to these problems, there are few antifungal agents available and it is necessary the development of novel therapeutic strat...
Screening of antimicrobial metabolite yeast isolates derived biome Ceará agains...
Andrade Neto, João Batista de; Silva, Cecília R. da; Nascimento, Francisca Bruna Stefany Aires do; Sampaio, Letícia Serpa; Silva, Anderson R. daAntimicrobials benefited the history of medicine by revolutionizing the treatment of infectious diseases. However, its consequent and continuous use has led to the emergence of microorganisms which once were considered safe, but have become feared as potentially lethal pathogens (Bowler et al., 2012). Staphylococcus aureus infections are highlighted for being a major cause of systemic infections, and for being ...
Antifungal activity of naphthoquinoidal compounds In vitro against fluconazole-...
Andrade Neto, João Batista de; Silva, Cecília R. da; Campos, Rosana S.; Siebra, Janaína T.; Silva, Rose A. C.; Gaspar, Danielle M.In recent decades, the incidence of candidemia in tertiary hospitals worldwide has substantially increased. These infections are a major cause of morbidity and mortality; in addition, they prolong hospital stays and raise the costs associated with treatment. Studies have reported a significant increase in infections by non-albicans Candida species, especially C. tropicalis. The number of antifungal drugs on the...
Potent antileukemic action of naphthoquinoidal compounds : evidence for an intr...
Cavalcanti, Bruno C.; Cabral, Igor O.; Rodrigues, Felipe A. R.; Barros, Francisco W. A.; Rocha, Danilo D.; Magalhães, Hemerson I. F.; Moura, Dinara J.The current study describes that nor-β-lapachone and its arylamino derivatives, iodinated and methylated naphthoquinones and nor-β-lapachone-based 1,2,3-triazoles exhibited pronounced cytotoxic effects against four human leukemia cell lines (HL-60, K562, Molt-4 and Jurkat). Nor-β- lapachones arylamino substituted with potent activity were identified, revealing themselves as potential prototypes against tumor ce...
(4-Methoxyphenyl)(3,4,5-trimethoxyphenyl)methanone inhibits tubulin polymerizat...
Magalhães, Hemerson I. F.; Wilke, Diego V.; Bezerra, Daniel P.; Cavalcanti, Bruno C.; Rotta, Rodrigo; Lima, Dênis P. de; Beatriz, Adilson(4-Methoxyphenyl)(3,4,5-trimethoxyphenyl)methanone (PHT) is a known cytotoxic compound belonging to the phenstatin family. However, the exact mechanism of action of PHT-induced cell death remains to be determined. The aim of this study was to investigate the mechanisms underlying PHT-induced cytotoxicity. We found that PHT displayed potent cytotoxicity in different tumor cell lines, showing IC50 values in the n...
Arylamino-nor-b-lapachone derivative-induced apoptosis in human prostate cancer...
Cavalcanti, Bruno C.; Magalhães, Hemerson I. F.; Rodrigues, Felipe A. R.; Moraes Filho, Manoel Odorico de; Pessoa, Cláudiab-lapachone, a DNA repair inhibitor, has been recognized as important prototype with activity against cancer cells devoided of cytotoxicity in non-tumor cells. NQO1 is a reductive enzyme that is important for the activation of many bioreductive quinones. Thus, differential levels of NQO1 in tissues, including tumors, can provide a target for an enzyme-directed approach to cancer therapy. Herein, we aimed to eva...
In vitro cytotoxic activity of Brazilian Middle West plant extracts
Mahmoud, Talal Suleiman [UNESP]; Marques, Maria Rita; Pessoa, Cláudia do Ó; Lotufo, Leticia V. C.; Magalhães, Hemerson I. F.; Moraes, Manoel O. deSubmitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T18:57:49Z No. of bitstreams: 1 S0102-695X2011000300017.pdf: 711209 bytes, checksum: 0aadb2d1954d80955d44caa2f22460cf (MD5); Made available in DSpace on 2013-08-22T18:57:49Z (GMT). No. of bitstreams: 1 S0102-695X2011000300017.pdf: 711209 bytes, checksum: 0aadb2d1954d80955d44caa2f22460cf (MD5) Previous issue date: 2011-06-01; Made availabl...
Genetic toxicology evaluation of essential oil of Alpinia zerumbet and its chem...
Cavalcanti, Bruno C.; Ferreira, José R. O.; Cabral, Igor O.; Magalhães, Hemerson I. F.; Oliveira, Cecília C. de; Rodrigues, Felipe A. R.Essential oil (EO) of Alpinia zerumbet leaves, at non-toxic concentrations (50–300 l g/mL), did not induce genotoxicity in human leukocytes. However, at the highest concentration (500 l g/mL) tested caused a reduction in cell proliferation and viability, and an increase in DNA damage. Moreover, in vivo experi- ments showed that EO (400 mg/kg) did not exert mutagenicity on peripheral blood cells and bone mar- ro...