Introduction. Cannabis-based edibles have become a lucrative and in-demand market. Despite not being legalized in Brazil, marijuana is found in oral preparations illegally marketed in the country and the search for these products has grown in recent years. The present study aims to gather data from the scientific literature on the physiology of the endocannabinoid system, effects of oral cannabis consumption, p...
The incidence of fungal infections has increased and it is necessary to seek new antifungals that also act against resistant strains. Palmatine is a protoberberine alkaloid noteworthy for its various pharmacological properties, including antifungal properties. The objective of this study was to evaluate the activity of palmatine against Candida spp. strains resistant to azole in planktonic cells and biofilm, an...
Poisonings are common occurrences, which annually take to the population the demand for specialized health service, with regard to emergency rooms around the world including Braz il. In 2010 it was registered about 90,000 cases of poisoning by exposure to various agents including accidents with animals, but it is estimated that the actual number is almost double of cases, since many incidents are not reported. ...
Recently, there has been a significant increase in invasive fungal infections, the treatment of which is limited to a quite small number of antifungal drugs. Natural products represent an important source of antifungal agents, mainly because of their natural coexistence with fungi present in each biome. Derivatives or semi-synthetic products can be used to optimize the pharmacological profile of natural product...
The study aimed to investigate the scientific evidence on the use of herbal medicines “Camellia sinensis”, “Citrus aurantium” and “Carthamus tinctorius” to help weight loss. In the development of this research we carried out systematic bibliographical studies in databases PubMed, ScienceDirect and Scielo between the years 2000-2014. According to the studies revised on the Camellia sinensis green tea extract has...
The incidence of fungal infections and, in particular, the incidence of fungal antibiotic resistance, which is associated with bio- film formation, have significantly increased, contributing to morbidity and mortality. Thus, new therapeutic strategies need to be developed. In this context, natural products have emerged as a major source of possible antifungal agents. Berberine is a pro- toberberine-type isoquin...
Candida species are the fourth most common cause of nosocomial bloodstream infections in the United States and the fifth to tenth most common causative pathogen in European studies Although C. albicans remains the most common fungal isolate recovered from blood, recent reports indicate a trend towards an increasing prevalence of infections caused by species of Candida other than C. albicans which are associated...
Flavonoids are a class of phenolic compounds commonly found in fruits, vegetables, grains, flowers, tea, and wine. They differ in their chemical structures and characteristics. Such compounds show various biological functions and have antioxidant, antimicrobial, anti-inflammatory, and antiapoptotic properties. The aim of this study was to evaluate the in vitro interactions of flavonoids with fluconazole against...
PURPOSE: To evaluate the genotoxicity of propolis and L-lysine, as well as their effects on the possible cellular damage in erythroblasts (bone marrow) and leukocytes (peripheral blood) caused by the carcinogen BBN (n – butyl – n {4 – hydroxybutyl} nitrosamine) in rats subjected to bladder carcinogenesis and treated with green propolis and L-lysine. METHODS: One hundred and twenty five rats were distributed int...
There have recently been significant increases in the prevalence of systemic invasive fungal infections. However, the number of antifungal drugs on the market is limited in comparison to the number of available antibacterial drugs. This fact, coupled with the increased frequency of cross-resistance, makes it necessary to develop new therapeutic strategies. Combination drug thera- pies have become one of the mos...