20 documents found, page 1 of 2

Feasibility and Effectiveness of a 12-Week Concurrent Exercise Training on Phys...

"Objective To examine the feasibility and effects of a 12-week exercise intervention on physical performance, muscular strength, and circulating myokines in frail individuals living in nursing homes. Design A cluster randomized, 2-period, 2-intervention crossover trial. Setting and Participants Frail residents of 9 nursing homes were randomly assigned to either 12 weeks of concurrent exercise training (n = 5, 2...

Avaliação do impacto de uma Dieta Hipoenergética cetogénica versus uma Dieta Hi...

Dose-response effect of a recreational team handball-based exercise programme o...

This study aimed at examining the dose-response of a recreational team handball (TH) exercise-based programme on cardiometabolic health and physical fitness in inactive middle-aged-to-elderly males without TH experience. Fifty-four inactive middle-aged-to-elderly men (67.5 +/- 4.2 years; stature 168.8 +/- 6.2 cm; body mass 78.4 +/- 10.7 kg; fat mass 27.1 +/- 5.3%; BMI 27.4 +/- 2.9 kg/m(2); VO2peak 27.3 +/- 4.8 ...

Transthyretin Promotes Axon Growth via Regulation of Microtubule Dynamics and T...

Transthyretin (TTR), a plasma and cerebrospinal fluid protein, increases axon growth and organelle transport in sensory neurons. While neurons extend their axons, the microtubule (MT) cytoskeleton is crucial for the segregation of functional compartments and axonal outgrowth. Herein, we investigated whether TTR promotes axon elongation by modulating MT dynamics. We found that TTR KO mice have an intrinsic incre...

Low bone turnover is associated with plain X-ray vascular calcification in pred...

Background Vascular calcification (VC) is a common finding in chronic kidney disease (CKD) patients and predicts subsequent cardiovascular morbidity and mortality in this population. Vascular calcification is linked to disordered mineral metabolism and has been associated with bone histomorphometry changes in CKD. However, data on predialysis patients is scarce. Methods A cross-sectional study was conducted on ...

Maternal high-fat high-sucrose diet and gestational exercise modulate hepatic f...

Background Maternal high-caloric nutrition and related gestational diabetes mellitus (GDM) are associated with a high-risk for developing metabolic complications later in life and in their offspring. In contrast, exercise is recognized as a non-pharmacological strategy against metabolic dysfunctions associated to lifestyle disorders. Therefore, we investigated whether gestational exercise delays the development...

Sclerostin and DKK1 circulating levels associate with low bone turnover in pati...

Background: Disordered mineral and bone metabolism is a common complication of chronic kidney disease (CKD). Bone biopsy remains the gold standard tool for evaluating renal osteodystrophy (ROD), but it is an invasive procedure. Despite a growing interest in the ability of newer bone biomarkers to discriminate between different forms of ROD, data on pre-dialysis patients are scarce. Methods: A cross-sectional st...

Microglia Dysfunction Caused by the Loss of Rhoa Disrupts Neuronal Physiology a...

Nervous tissue homeostasis requires the regulation of microglia activity. Using conditional gene targeting in mice, we demonstrate that genetic ablation of the small GTPase Rhoa in adult microglia is sufficient to trigger spontaneous microglia activation, producing a neurological phenotype (including synapse and neuron loss, impairment of long-term potentiation [LTP], formation of ß-amyloid plaques, and memory ...

Effects of a 16-week recreational team handball intervention on aerobic perform...

Background: Postmenopausal women have an elevated risk of developing cardiovascular diseases, which can be counteracted by conventional exercise regimes or recreational football. Less is known about the impact of exercise programmes based on other team sports. Thus, we examined the effects of recreational team handball on aerobic performance, cardiorespiratory fitness and cardiometabolic health in untrained pos...

Optimization of rifapentine-loaded lipid nanoparticles using a Quality-by-Desig...

This work aims to optimize and assess the potential use of lipid nanoparticles, namely nanostructured lipid carriers (NLCs), as drug delivery systems of rifapentine (RPT) for the treatment of tuberculosis (TB). A Box-Behnken design was used to increase drug encapsulation efficiency (EE) and loading capacity (LC) of RPT-loaded NLCs. The optimized nanoparticles were fully characterized, and their effect on cell v...