5 documents found, page 1 of 1
Opioids and constipation therapy in the last week of life: Their impact on pati...
Ribeiro, Hugo; Magalhães, Júlia; Cardoso, Tatiana; Chaves-Castro, Isabel; Lopes-Mota, Carla; Costa, Elisabete; Rocha, Patrícia da; Lopes, LuísaThe use of opioids to control pain at the end of life may cause constipation, a symptom that can negatively influence the well-being of patients and caregivers. The main aim of this study was to evaluate the impact of constipation on symptomatic control and patients' overall quality of life at this stage. A particular focus was placed on opioids. We also intended to investigate whether constipation and caregive...
Development of electrochemical genosensors for the CYPC*2 gene polymorphism det...
Sousa, António J. S. F.; Costa, Inês; Banegas, Rodrigo S.; Morais, Stephanie L.; Magalhães, Júlia; Rodrigues, Valentina; Delerue-Matos, CristinaPharmacogenetic studies search for heritable genetic polymorphisms that influence responses to drug therapy. Pharmacogenetics has many possible applications in cardiovascular pharmacotherapy including screening for polymorphisms to choose agents with the greatest potential for efficacy and least risk of toxicity. Pharmacogenetics also informs dose adaptations for specific drugs in patients with aberrant metabol...
VKORC1 gene polymorphism as cardiovascular biomarker: Detection by electrochemi...
Costa, Inês; J. S. F. Sousa, António; Banegas, Rodrigo S.; Morais, Stephanie L.; Magalhães, Júlia; Rodrigues, Valentina; Delerue-Matos, CristinaWarfarin is an anticoagulant generally used to prevent cardiovascular diseases. Since of the low therapeutic index of warfarin and frequent complications of prevention or treatment, significant differences in individual doses of warfarin are needed to achieve prophylactic and therapeutic ranges. Recent studies have been reporting that genetic variants of vitamin K epoxide reductase complex (VKORC1) influence th...
Effects of the reactive moiety of phenolipids on their antioxidant efficiency i...
Costa, Marlene; Losada-Barreiro, Sonia; Magalhães, Júlia; Monteiro, Luís S.; Bravo-Díaz, Carlos; Paiva-Martins, FátimaOur previous research was focused on the effects of hydrophobicity on the antioxidant (AO) efficiency of series of homologous antioxidants with the same reactive moieties. In this work we evaluate the antioxidant efficiency of hydrophobic phenolipids in 4:6 olive oil-in-water emulsions, with different phenolic moieties (derived from caffeic, 4-hydroxycinnamic, dihydrocaffeic acids, tyrosol and hydroxytyrosol), ...
Salt content in bread and dough from northern Portugal: method development and ...
Plácido, Alexandra; Kupers, Ruth; Paíga, Paula; Magalhães, Júlia; Nouws, Henri P. A.; Delerue-Matos, Cristina; Oliveira, M. Beatriz P. P.In the initial stage of this work, two potentiometric methods were used to determine the salt (sodium chloride) content in bread and dough samples from several cities in the north of Portugal. A reference method (potentiometric precipitation titration) and a newly developed ion-selective chloride electrode (ISE) were applied. Both methods determine the sodium chloride content through the quantification of chlor...