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Neuronal control of microglia through the mitochondria

Pereira-Santos, A. R.; Candeias, Emanuel; Magalhães, J. D.; Empadinhas, Nuno; Esteves, A. Raquel; Cardoso, Sandra Morais

The microbial toxin β-N-methylamino-L-alanine (BMAA), which is derived from cyanobacteria, targets neuronal mitochondria, leading to the activation of neuronal innate immunity and, consequently, neurodegeneration. Although known to modulate brain inflammation, the precise role of aberrant microglial function in the neurodegenerative process remains elusive. To determine if neurons signal microglial cells, we tr...

Date: 2024   |   Origin: Estudo Geral - Universidade de Coimbra
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