2 documents found, page 1 of 1
Vulnerability of progeroid smooth muscle cells to biomechanical forces is media...
Pitrez, Patrícia R.; Estronca, Luís Miguel Beicinha Branco; Monteiro, Luís Miguel Marques; Colell, Guillem; Vazão, HelenaHutchinson-Gilford Progeria Syndrome (HGPS) is a premature aging disease in children that leads to early death. Smooth muscle cells (SMCs) are the most affected cells in HGPS individuals, although the reason for such vulnerability remains poorly understood. In this work, we develop a microfluidic chip formed by HGPS-SMCs generated from induced pluripotent stem cells (iPSCs), to study their vulnerability to flow...
miRNA-31 Improves Cognition and Abolishes Amyloid-β Pathology by Targeting APP ...
Barros-Viegas, Ana Teresa; Carmona, Vitor; Ferreiro, Elisabete; Guedes, Joana; Cardoso, Ana Maria S.; Cunha, Pedro; Almeida, Luís Pereira deAlzheimer's disease (AD) is the most common form of dementia worldwide, characterized by progressive memory impairment, behavioral changes, and, ultimately, loss of consciousness and death. Recently, microRNA (miRNA) dysfunction has been associated with increased production and impaired clearance of amyloid-β (Aβ) peptides, whose accumulation is one of the most well-known pathophysiological markers of this dise...