8 documents found, page 1 of 1
Practical Guidance on the Detection of NTRK Fusions in Sarcomas: Current Status...
Fernandes, Isabel; Macedo, Daniela; Gouveia, Emanuel; Ferreira, Ana; Lima, Jorge; Lopez, Dolores; Melo-Alvim, Cecília; Carvalho, Alice; Tavares, PauloSarcomas are a rare and heterogeneous group of mesenchymal malignant tumors and account for approximately 1% of all adult cancers and around 20% of all pediatric solid tumors in Europe. Technology advances have enabled a more accurate and efficient characterization of the molecular mechanisms underlying the pathogenesis of sarcoma subtypes and revealed novel and unexpected therapeutic targets with prognostic/pr...
Ewing Sarcoma Developed at the Site of Previous Mast Cell Proliferation
Ranchor, Ridhi; Magalhães, Manuel; Rosendo, Eugénia; Coelho, André; Cardoso, PedroKIT gene mutations in Ewing sarcomas are rare; however, they are much more frequent in other neoplasms, namely mastocytosis. We describe a case of an adult male with a one-year duration of recurrent episodes of pain, swelling, and redness on the proximal phalanx of the third finger of his right hand. A core biopsy suggested a possible mastocytosis. After four years of recurrent episodes and worsening symptoms, ...
Combined image-based approach for monitoring the adherence to inhaled medications
Vieira-Marques, Pedro; Teixeira, João Fonseca; Valente, José; Pinho, Bernardo; Guedes, Rui; Almeida, Rute; Jácome, Cristina; Pereira, AnaThe adherence to inhaled controller medications is of critical importance to achieve good clinical results in patients with chronic respiratory diseases. To objectively verify the adherence, a detection tool was previously developed and integrated in the mobile application InspirerMundi, based on image processing methods. In this work, a new approach for enhanced adherence verification was developed. In a first...
Maxillary mesenchymal chondrosarcoma leading to a diagnosis of Li-Fraumeni synd...
Ventura, Eduardo; Dionísio, Sílvia; Ferreira, Ângela; Saleiro, Rute; Marques, Hugo; Magalhães, Manuel; Monteiro, CarlosMesenchymal chondrosarcoma (MCS) is a rare histological variant of chondrosarcoma, with aggressive behaviour. Due to the unique nature of this disease, management strategies are not well established. Li-Fraumeni syndrome (LFS) is a rare cancer predisposition syndrome with a wide tumour spectrum, associated with TP53 germline mutations. We report a case of MCS of the maxilla, treated with surgical excision and a...
Prevalence of atrial fibrillation and antithrombotic therapy in a group of prim...
Oliveira, Diana; Coelho, Joana; Magalhães, Manuel; Oliveira, MarianaObjectives: To determine the prevalence of atrial fibrillation among patients in primary health care clinics in West Porto in May 2013, to assess the distribution of CHA2DS2VASc risk factors for thromboembolism, to study antithrombotic therapy and the sites where anticoagulation therapy is managed. Type of Study: Cross-sectional study. Setting: Primary Health Care Centres of West Porto. Population: Patients reg...
A study of multiple deliveries in Portugal: indications of an Iberian Peninsula...
Fuster, Vicente; Santos, Carlota; Román-Busto, Jorge; Magalhães, ManuelInformation on multiple deliveries with regard to Portugal is scarce. Based on data provided by the Portuguese Institute of Statistics (INE), the rates for double and triple deliveries were calculated since 1930. The results obtained show for twins a uniform temporal pattern up to the 1970s. At this time rates decreased, but later they gradually recovered, reaching their maximum level in 2010. For triplets, the...
A nova sociologia institucional e a fixação de taxas municipais: estudo em auta...
Magalhães, Manuel; Leite, JoaquimEsta investigação pretendeu realçar o peso de factores institucionais na dispersão das taxas municipais fixadas. Os municípios portugueses dos distritos de Bragança, Vila Real, Porto, Braga e Viana do Castelo foram objecto de estudo, especificamente para as taxas de emissão de cartão de vendedor ambulante, utilização de lugares de terrado por m2 ou fracção, por dia em feiras e emissão de licença de motociclos, ...
A nova sociologia institucional e a fixação de taxas municipais: estudo em auta...
Magalhães, Manuel; Leite, JoaquimEsta investigação pretendeu realçar o peso de factores institucionais na dispersão das taxas municipais fixadas. Os municípios portugueses dos distritos de Bragança, Vila Real, Porto, Braga e Viana do Castelo foram objecto de estudo, especificamente para as taxas de emissão de cartão de vendedor ambulante, utilização de lugares de terrado por m2 ou fracção, por dia em feiras e emissão de licença de motociclos, ...