28 documents found, page 1 of 3
Deciphering the influence of CD276 glycocode in gastric cancer immunoregulation
Magalhães, Mariana; Dourado-Gonçalves, Martina; Santos, Lúcio Lara; Peixoto, Andreia; Ferreira, José AlexandreGastric cancer (GC) ranks 5th globally in incidence and cancer-related mortality, with advanced-stage 5-year survival rates below 20%1,2, unveiling the need for novel immunotherapies. CD276, an immune checkpoint molecule, is related to immune evasion and tumour progression in GC3-5. In turn, aberrant glycosylation, especially truncated O-glycans, Tn and Sialyl-Tn, correlates with GC aggressiveness and poor prog...
Unveiling the antitumor mechanism of 7α-acetoxy-6β-hydroxyroyleanone from Plect...
Magalhães, Mariana; Domínguez-Martín, Eva María; Jorge, Joana; Gonçalves, Ana Cristina; Massenzio, Francesca; Spigarelli, RenatoGlioblastoma (GB) is the most aggressive and prevalent glioma within the central nervous system. Despite considerable efforts, GB continues to exhibit a dismal 5-year survival rate (∼6%). This is largely attributed to unfavorable prognosis and lack of viable treatment options. Therefore, novel therapies centered around plant-derived compounds emerge as a compelling avenue to enhance patient survival and well-be...
Essential Oils from Côa Valley Lamiaceae Species: Cytotoxicity and Antiprolifer...
Marques, Mário Pedro; Neves, Beatriz Guapo; Varela, Carla Lopes; Zuzarte, Mónica; Gonçalves, Ana Cristina; Dias, Maria Inês; Amaral, Joana S.Lavandula pedunculata (Mill.) Cav., Mentha cervina L. and Thymus mastichina (L.) L. subsp. mastichina are representative species of the Côa Valley's flora, a Portuguese UNESCO World Heritage Site. L. pedunculata and T. mastichina are traditionally used to preserve olives and to aromatize bonfires on Saint John's Eve, while M. cervina is mainly used as a spice for river fish dishes. Despite their traditional use...
Essential oils from coa valley lamiaceae species: cytotoxicity and antiprolifer...
Marques, Mário Pedro; Neves, Beatriz Guapo; Varela, Carla; Zuzarte, Mónica; Goncalves, Ana Cristina; Dias, Maria Inês; Amaral, Joana S.; Barros, LillianLavandula pedunculata (Mill.) Cav., Mentha cervina L. and Thymus mastichina (L.) L. subsp. mastichina are representative species of the Coa Valley's flora, a Portuguese UNESCO World Heritage Site. L. pedunculata and T. mastichina are traditionally used to preserve olives and to aromatize bonfires on Saint John's Eve, while M. cervina is mainly used as a spice for river fish dishes. Despite their traditional use...
Essential oils from Côa Valley Lamiaceae species: cytotoxicity on glioblastoma ...
Marques, Mário Pedro; Delgado, Jéssica; Zuzarte, Mónica; Varela, Carla; Dias, Maria Inês; Barros, Lillian; Magalhães, Mariana; Cabral, CéliaLavandula pedunculata (Mill.) Cav., Mentha cervina L. and Thymus mastichina (L) L. subsp. mastichina are widely used and fairly representative species of the flora and traditional uses of the Côa Valley, a Portuguese UNESCO World Heritage Site. L. pedunculata and T. mastichina are used by local populations to preserve olives, as a condiment in traditional cuisine and to aromatize bonfires on Saint John's Eve, w...
Satisfaction with the police: perceptions and related variables from an urban c...
Sani, Ana Isabel; Azevedo, Vanessa; Paulo, Daniela; Magalhães, Mariana; Nunes, Laura M.This quantitative, correlational, and transversal study was performed with a sample of 482 participants from an urban community at the Historic Centre of Porto (HCP). Participants answered to an enquiry designed to collect information about (dis)satisfaction with the police and its performance, with sociodemographic, victimisation, criminal, environmental, social control, and community variables as potential pr...
Predicting frequent and feared crime typologies: individual and social/environm...
Caridade, Sónia; Magalhães, Mariana; Azevedo, Vanessa; Dinis, Maria Alzira Pimenta; Maia, Rui Leandro; Estrada, Rui; Sani, Ana Isabel; Nunes, Laura M.The lack of organisation in urban spaces plays a decisive role in the level of integration, communication and social bonds of the residents, impacting the citizens’ feelings of trust and security. Different personal variables and contextual characteristics have been associated with the fear of crime (FOC). The main objective of this study is to analyse how individual and social/environmental variables, and inci...
Predicting frequent and feared crime typologies: individual and social/environm...
Caridade, Sónia Maria Martins; Magalhães, Mariana; Azevedo, Vanessa; Dinis, Maria Alzira Pimenta; Maia, Rui Leandro; Estrada, Rui; Sani, Ana IsavelThe lack of organisation in urban spaces plays a decisive role in the level of integration, communication and social bonds of the residents, impacting the citizens’ feelings of trust and security. Different personal variables and contextual characteristics have been associated with the fear of crime (FOC). The main objective of this study is to analyse how individual and social/environmental variables, and inci...
Predicting Frequent and Feared Crime Typologies: Individual and Social/Environm...
Caridade, S.; Magalhães, Mariana; Azevedo, Vanessa; Dinis, Maria Alzira Pimenta; Maia; Estrada, Rui; Sani, Ana; Nunes, L. M.The lack of organisation in urban spaces plays a decisive role in the level of integration, communication and social bonds of the residents, impacting the citizens’ feelings of trust and security. Different personal variables and contextual characteristics have been associated with the fear of crime (FOC). The main objective of this study is to analyse how individual and social/environmental variables, and inci...
Kawasaki disease in a five-month-old infant
Maciel, Juliana; Meireles, Daniel; Magalhães, Mariana; Gonçalves, Sara; Fernandes, Sofia Ribeiro; Fernandes, Paula CristinaIntroduction: Kawasaki disease, an acute self-limited vasculitis of small and medium arteries of unknown etiology, is the leading cause of heart disease in children in most developed countries. If untreated, it can lead to coronary artery dilatation and aneurysm, placing patients at risk for coronary thrombosis, myocardial infarction, or sudden death. Case Report: A previously healthy five-month-old boy presen...