11 documents found, page 1 of 2
Contribuição ao estudo fitoquímico dos frutos de batiputa (ouratea fieldingiana...
Pinto, Talita Rocha de Miranda; Magalhães, Pedro Jorge Caldas; Fonseca, Said Gonçalves da Cruz; Bandeira, Mary Anne MedeirosIntrodução: Batiputá (Ouratea fieldingiana (Gardner) Engl.) é uma planta essencialmente arbórea ou arbustiva, pertencente ao gênero Ouratea sp, da família Ochnaceae, encontrada em tabuleiros litorâneos do Ceará. As espécies desse gênero são utilizadas popularmente como tônicas e adstringentes, como antinflamatório e em doenças da pele e no tratamento de doenças gástricas. Estudos científicos dos extratos e fraç...
Side-effects of irinotecan (CPT-11), the clinically used drug for colon cancer ...
Alencar, Nylane Maria Nunes de; Bitencourt, Flávio da Silveira; Figueiredo, Ingrid Samantha Tavares de; Luz, Patrícia BastosIntestinal mucositis (IM) is the critical side effect of irinotecan (CPT-11), which is the front-line drug used for the treatment of colorectal cancer. This study aimed to evaluate the effectiveness of latex proteins (LP) from Calotropis procera to prevent IM and diarrhea in animals. Swiss mice were treated daily with saline or LP (1, 5, or 50 mg/kg, i.v.) 24 h prior to CTP-11 (75 mg/kg/4 days, i.p) and for add...
The triterpenoid alpha, beta-amyrin prevents the impaired aortic vascular react...
Santos, Flávia Almeida; Batista-Lima, Francisco José; Nunes, Paulo Iury Gomes; Viana, Ana Flávia Seraine CustódioTo characterize the pro tective effects of the triterpenoid mixture alpha, beta-amyrin (AMY, 20 mg/kg, during 15 days) on the reactivity of isolated aorta of high- fat diet (HFD)-induced obese mice. Male Swiss mice were fed with HFD or normal diet (ND) for 15 weeks. Contractions of thoracic aorta in response to KCl or phen- ylephrine (PHE) and relaxation by acetylcholine (ACh) or sodium nitroprusside (SNP) were...
(−)-α-Bisabolol inhibits preferentially electromechanical coupling on rat isola...
Siqueira, Rodrigo José Bezerra de; Ribeiro-Filho, Helder Veras; Freire, R. S.; Freire, W. B. S.; Vasconcelos-Silva, A. A.; Soares, M. A.; Lahlou, SaadPrevious findings enable us to hypothesize that (−)-α-bisabolol acts as inhibitor of voltage-dependent Ca2+ channels in smooth muscle. The current studywas aimed at consolidating such hypothesis through the recording of isometric tension, measurement of intracellular Ca2+ as well as discovery of channel target using in silico analysis. In rat aortic rings, (−)-α-bisabolol (1–1000 μM) relaxed KCl- and phenylephr...
Atrial stretch delays gastric emptying of liquids in awake rats
Palheta Júnior, Raimundo Campos; Silva, Moisés Tolentino Bento da; Barbosa, H. L. G.; Pinheiro, Ana Débora Nunes; Cardoso, KKátia Virgínia VianaAims: We previously reported that mechanical atrial stretch (AS) by balloon distention increased gastric tonus in anesthetized rats. The present study evaluated the effect of AS on the gastric emptying of a liquid test meal in awake rats and its underlying neural mechanisms. Main methods: Anesthetizedmale rats received a balloon catheter into the right atrium and a gastrostomy cannula. The next day,mean arteria...
Linalool-rich rosewood oil induces vago-vagal bradycardic and depressor reflex ...
Siqueira, Rodrigo José de; Rodrigues, Karilane Maria Silvino; Silva, Moisés Tolentino Bento da; Correia Junior, Carlos Antônio BarrosCardiovascular effects of the linalool-rich essential oil of Aniba rosaeodora (here named as EOAR) in normotensive rats were investigated. In anesthetized rats, intravenous (i.v.) injection of EOAR induced dosedependent biphasic hypotension and bradycardia. Emphasis was given to the first phase (phase 1) of the cardiovascular effects, which is rapid (onset time of 1–3 s) and not observed in animals submitted to...
Talking about bioelectrical potentials using rings of the mesenteric artery wit...
Ribeiro-Filho, Helder Veras; Brito, Teresinha Silva de; Lima, F. J. B.; Pinho, J. P. M.; Sousa, D. F.; Silva, Moisés Tolentino Bento daIn the present study, a practical activity is proposed to adopt an experimental approach to demonstrate the relationship between the equilibrium potential for K and transmembrane electrical potential without glass micropipettes. A conventional setup for recording contractile activity of isolated smooth muscle preparations was used based on the events elegantly described by Somlyo and Somlyo in the 1960s. They s...
Phytochemical study guided by the myorelaxant activity of the crude extract, fr...
Bezerra, Gabrieli Penha; Góis, Roberto Wagner da Silva; Brito, TeresinhaSilvade; Lima, Francisco José Batista de; Bandeira, Mary Anne MedeirosEthnopharmacological relevance:Hymenaeacourbaril L. (Caesalpinoideae)isusedinBrazilianfolkmedicine totreatanemia,kidneyproblems,sorethroatandotherdysfunctionsoftherespiratorysystem,suchas bronchitisandasthma,althoughsuchpropertiesareyettobescientificallyvalidated. Aimofthestudy: Inordertogiveascientific basistosupportthetraditionaluseof Hymenaea courbaril, this study wasdesignedtoevaluateantioxidant,myorelaxant...
Mechanisms underlying the cardiovascular effects of a labdenic diterpene isolat...
Lahlou, Saad; Correia Junior, Carlos Antônio de Barros; Santos, Márcio Vasconcelos dos; David, Jorge Mauricio; David, Juceni Pereira de LimaRESTRITO; Submitted by Santiago Fabio (fabio.ssantiago@hotmail.com) on 2012-07-03T15:02:01Z No. of bitstreams: 1 AA.pdf: 226361 bytes, checksum: ed917aff58751bf94ff7f571e987446c (MD5); Made available in DSpace on 2012-07-03T15:02:01Z (GMT). No. of bitstreams: 1 AA.pdf: 226361 bytes, checksum: ed917aff58751bf94ff7f571e987446c (MD5) Previous issue date: 2006; Cardiovascular effects of Labd-8 (17)-en-15-oic acid (...
Estudo farmacologico do óleo essencial do Croton nepetaefolius Baill sobre os m...
Magalhães, Pedro Jorge CaldasCroton nepetaefolius is an aromatic bush found in brazilian Northeast region, called “marmeleiro sabiá”, and it is used in folk medicine as an antispasmodic and carminative agent. Its essential oil is comprised of 1,8-cineole, methyl-eugenol, xanthoxylin, terpineol and others constituents. Recent studies showed some pharmacological activities of the essential oil of Croton nepetaefolius (EOCN) as an intestinal ...