23 documents found, page 1 of 3
Alterations in functional connectivity are associated with white matter lesions...
Soares, José Miguel Montenegro; Conde, Raquel; Magalhães, Ricardo José Silva; Marques, Paulo César Gonçalves; Magalhaes, Rosana; Gomes, LucianaFunctional connectivity (FC) is typically altered in individuals with Multiple Sclerosis (MS). However, in relapsing-remitting multiple sclerosis (RRMS) patients, the relationship between brain FC, tissue integrity and cognitive impairment is still unclear as contradictory findings have been documented. In this exploratory study we compared both the whole brain connectome and resting state networks (RSNs) FC of...
Brain functional connectivity is altered in patients with Takotsubo Syndrome
Silva, Ana Rita; Magalhães, Ricardo José Silva; Arantes, Carina; Moreira, Pedro Miguel Silva; Rodrigues, Mariana; Marques, Paulo; Marques, JorgeTakotsubo syndrome (TTS) is an acute, reversible cardiomyopathy. The central autonomic nervous system (ANS) is believed to play a role in this disease. The aim of the present study was to investigate the patterns of brain functional connectivity in a sample of patients who had experienced a previous episode of TTS. Brain functional connectivity, both at rest and in response to the stressful stimulus of topical ...
Evidence for lack of direct causality between pain and affective disturbances i...
Guimarães, Marco Rafael Machado; Soares, Ana R.; Cunha, Ana M.; Esteves, Madalena; Borges, Sónia; Magalhães, Ricardo José SilvaChronic pain is frequently accompanied by the manifestation of emotional disturbances and cognitive deficits. While a causality relation between pain and emotional/cognitive disturbances is generally assumed, several observations suggest a temporal dissociation and independent mechanisms. We therefore studied Sprague-Dawley rats that presented a natural resistance to pain manifestation in a neuropathy model (sp...
A resting-state functional MR imaging and spectroscopy study of the dorsal hipp...
Magalhães, Ricardo José Silva; Novais, Ashley; Barrière, David A.; Marques, Paulo; Marques, Fernanda; Sousa, João Carlos; Cerqueira, João JoséExposure to chronic stress leads to an array of anatomical, functional, and metabolic changes in the brain that play a key role in triggering psychiatric disorders such as depression. The hippocampus is particularly well known as a target of maladaptive responses to stress. To capture stress-induced changes in metabolic and functional connectivity in the hippocampus, stress-resistant (low-responders) or -suscep...
Structural and functional alterations in the retrosplenial cortex following neu...
Barrière, David André; Hamieh, Al Mahdy; Magalhães, Ricardo José Silva; Traoré, Amidou; Barbier, Julie; Bonny, Jean-Marie; Ardid, DenisHuman and animal imaging studies demonstrated that chronic pain profoundly alters the structure and the functionality of several brain regions. In this article, we conducted a longitudinal and multimodal study to assess how chronic pain affects the brain. Using the spared nerve injury model which promotes both long-lasting mechanical and thermal allodynia/hyperalgesia but also pain-associated comorbidities, we ...
The dynamics of stress: a longitudinal MRI study of rat brain structure and con...
Magalhães, Ricardo José Silva; Barrière, D. A.; Novais, Ashley Cruz; Marques, Fernanda; Marques, Paulo César Gonçalves; Cerqueira, João JoséStress is a well-established trigger for a number of neuropsychiatric disorders, as it alters both structure and function of several brain regions and its networks. Herein, we conduct a longitudinal neuroimaging study to assess how a chronic unpredictable stress protocol impacts the structure of the rat brain and its functional connectome in both high and low responders to stress. Our results reveal the changes...
Functional Hemispheric (A)symmetries in the Aged Brain-Relevance for Working Me...
Esteves, Madalena; Magalhães, Ricardo José Silva; Marques, Paulo; Castanho, Teresa Jesus Costa; Portugal-Nunes, Carlos; Soares, José M.Functional hemispheric asymmetries have been described in different cognitive processes, such as decision-making and motivation. Variations in the pattern of left/right activity have been associated with normal brain functioning, and with neuropsychiatric diseases. Such asymmetries in brain activity evolve throughout life and are thought to decrease with aging, but clear associations with cognitive function hav...
Safinamide: a new hope for Parkinson's disease?
Teixeira, Fábio Gabriel Rodrigues; Gago, Miguel F.; Marques, Paulo César Gonçalves; Moreira, Pedro Miguel Silva; Magalhães, Ricardo José SilvaThe loss of dopaminergic neurons (DAn) and reduced dopamine (DA) production underlies the reasoning behind the gold standard treatment for Parkinson's disease (PD) using levodopa (L-DOPA). Recently licensed by the European Medicine Agency (EMA) and US Food and Drug Administration (FDA), safinamide [a monoamine oxidase B (MOA-B) inhibitor] is an alternative to L-DOPA; as we discuss here, it enhances dopaminergic...
The association between stress and mood across the adult lifespan on default mo...
Soares, José Miguel Montenegro; Marques, Paulo César Gonçalves; Magalhães, Ricardo José Silva; Santos, Nadine Correia; Sousa, NunoAging of brain structure and function is a complex process characterized by high inter- and intra-individual variability. Such variability may arise from the interaction of multiple factors, including exposure to stressful experience and mood variation, across the lifespan. Using a multimodal neuroimaging and neurocognitive approach, we investigated the association of stress, mood and their interaction, in the ...
A knowledge representation and reasoning system for multimodal neuroimaging stu...
Coelho, Ana; Marques, Paulo César Gonçalves; Magalhães, Ricardo José Silva; Sousa, Nuno; Neves, José; Alves, VictorMultimodal neuroimaging analyses are of major interest for both research and clinical practice, enabling the combined evaluation of the structure and function of the human brain. These analyses generate large volumes of data and consequently increase the amount of possibly useful information. Indeed, BrainArchive was developed in order to organize, maintain and share this complex array of neuroimaging data. It ...