7 documents found, page 1 of 1
Guidelines on myelodysplastic syndromes: Associação Brasileira de Hematologia, ...
Magalhães, Silvia Maria Meira; Niero-Melo, Lígia [UNESP]; Chauffaille, Maria de Lourdes Lopes Ferrari; Velloso, Elvira Deolinda Rodrigues PereiraMade available in DSpace on 2018-12-11T17:24:18Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-07-01; Hospital Universitário Walter Cantídio - Universidade Federal do Ceará (HUWC UFC); Faculdade de Medicina de Botucatu da Universidade Estadual Paulista (FMB Unesp); Escola Paulista de Medicina da Universidade Federal de São Paulo (EPM Unifesp); Hospital das Clínicas Faculdade de Medicina Universidade de ...
Interleukin-8 and nuclear factor kappa B are increased and positively correlate...
Matos, Anacélia Gomes de; Ribeiro Junior, Howard Lopes; Borges, Daniela de Paula; Okubo, Bruno Memória; Sousa, Juliana Cordeiro deThe pathogenesis of myelodysplastic syndromes (MDS) is complex and depends on the interaction between aberrant hematopoietic cells and their microenvironment, probably including aberrations in cytokines and their signaling pathways. To evaluate interleukin-8 (IL-8) plasma levels and nuclear factor kappa B (NF-kB) in patients with MDS and to test possible correlation between IL-8 and NFKb, a total of 45 individu...
Myelodysplastic syndrome patients present more severe respiratory muscle impair...
Okubo, Bruno Memória; Matos, Anacélia Gomes de; Ribeiro Junior, Howard Lopes; Borges, Daniela de Paula; Oliveira, Roberta Taiane Germano deThe ageing process is associated with gradual decline in respiratory system performance. Anemia is highly prevalent among older adults and usually associated with adverse outcomes. Myelodysplastic syndromes (MDS) are a heterogeneous group of hematologic malignancies with increasing incidence with age and characterized by anemia and other cytopenias. The main objectives of this study were to evaluate respiratory...
New polymorphisms of Xeroderma Pigmentosum DNA repair genes in myelodysplastic ...
Santiago, Sabrina Pinheiro; Ribeiro Junior, Howard Lopes; Sousa, Juliana Cordeiro de; Borges, Daniela de Paula; Oliveira, Roberta Taiane Germano deThe association between Xeroderma Pigmentosum DNA repair genes ( XPA rs1800975, XPC rs2228000, XPD rs1799793 and XPF rs1800067) polymorphisms and myelodysplastic syndrome (MDS) have not been reported. To assess the functional role between these polymorphisms and MDS, we evaluated 189 sam- ples stratified in two groups: 95 bone marrow samples from MDS patients and 94 from healthy elderly volunteers used as contr...
HFE gene mutation and oxidative damage biomarkers in patients with myelodysplas...
Souza, Geane Felix de; Ribeiro Jr, Howard Lopes; Sousa, Juliana Cordeiro de; Heredia, Fabíola Fernandes; Freitas, Rivelilson Mendes deObjective: A relation between transfusional IOL (iron overload), HFE status and oxidative damage was evaluated. Design, setting and participants: An observational cross-sectional study involving 87 healthy individuals and 78 patients with myelodysplastic syndromes (MDS) with and without IOL, seen at University Hospital of the Federal University of Ceará, Brazil, between May 2010 and September 2011. Methods: IOL...
Increased parameters of oxidative stress and its relation to transfusion iron o...
Souza, Geane Felix de; Barbosa, Maritza Cavalcante; Santos, Talyta Ellen de Jesus; Carvalho, Teresa Maria de Jesus Ponte; Freitas, Rivelilson Mendes deMyelodysplastic syndromes (MDS) are group of stem cell disorders characterised by peripheral cytopaenias and a variable risk of progression to acute myeloid leukaemia. Most patients have anaemia and many develop transfusion dependence and iron overload (IOL), considered to be a negative independent prognostic factor associated with a higher risk of leukemic transformation and shorter survival.
Nodulos linfoides medulares em pacientes portadores de sindrome mielodisplasica...
Magalhães, Silvia Maria MeiraOrientadores : Irene Lorand-Metze, Jose Vassallo; Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas; Resumo: Síndromes mielodisplásicas (SMD) são um grupo heterogêneo de desordens caracterizado por anormalidades na proliferação e maturação dos precursores hematopoéticos, resultando em citopenias periféricas e potencial para transformação leucêmica. Nódulos linfóides (NL) medula...