18 documents found, page 1 of 2
22β-hydroxytingenone induces apoptosis and suppresses invasiveness of melanoma ...
Aranha, Elenn Suzany Pereira; Portilho, Adrhyann Jullyanne de Sousa; Sousa, Leilane Bentes de; Silva, Emerson Lucena da; Mesquita, Felipe PantojaEthnopharmacological relevance: 22β-hydroxytingenone (22-HTG) is a quinonemethide triterpene isolated from Salacia impressifolia (Miers) A. C. Smith (family Celastraceae), which has been used in traditional medicine to treat a variety of diseases, including dengue, renal infections, rheumatism and cancer. However, the anticancer effects of 22-HTG and the underlying molecular mechanisms in melanoma cells have no...
SARS‑COV‑2 infection outcomes in patients with congenital generalized lipodystr...
Madeira, Mayara Ponte; Freire, Erika Bastos Lima; Fernandes, Virginia Oliveira; Lima, Grayce Ellen da Cruz Paiva; Melo, Ivana da PonteBackground: A new strain of human coronavirus (HCoV) spread rapidly around the world. Diabetes and obesity are associated with a worse prognosis in these patients. Congenital Generalized Lipodystrophy (CGL) patients generally have poorly controlled diabetes and require extremely high doses of insulin. There is no documentation in the literature of cases of COVID in CGL patients. Thus, we aimed to evaluate the p...
Kinase inhibition in relapsed/refractory leukemia and lymphoma settings: recent...
Machado, Caio Bezerra; Pessoa, Flávia Melo Cunha de Pinho; Silva, Emerson Lucena da; Pantoja, Laudreísa da Costa; Ribeiro, Rodrigo MonteiroCancer is still a major barrier to life expectancy increase worldwide, and hematologic neoplasms represent a relevant percentage of cancer incidence rates. Tumor dependence of continuous proliferative signals mediated through protein kinases overexpression instigated increased strategies of kinase inhibition in the oncologic practice over the last couple decades, and in this review, we focused our discussion on...
Análise in silico da farmacocinética e farmacodinâmica do composto benzotiazóli...
Mesquita, Felipe Pantoja; Lima, Luina Benevides; Daniel, Julio Paulino; Portilho, Adrhyann Jullyanne de Sousa; Oliveira, Lais Lacerda Brasil deGastric adenocarcinoma has high incidence and mortality rates worldwide. The aim of this study was to evaluate the antitumor activity of benzothiazole AFN01 against ACP03 gastric adenocarcinoma cell line. Furthermore, computational prediction of the pharmacokinetics and pharmacodynamics of this molecule and the molecular docking with the relevant pharmacological target found were performed. The MTT assay was pe...
O uso de linhagens leucêmicas e a sua importância na oncologia experimental
Sales, Lívia de Oliveira; Nogueira, Beatriz Maria Dias; Silva, Emerson Lucena da; Moraes, Maria Elisabete Amaral de; Montenegro, Raquel CarvalhoExperimental oncology is based on a model of study through cell culture, a technique frequently used for the study of cancer biology and for tests of new anticancer therapies. This model provides an appropriate system for researching the effects of drugs and toxic compounds on cells, mutagenesis and carcinogenesis, in drug screening and development. In addition the cell lines allows consistent and reproducible ...
Biological activity of neosergeolide and isobrucein B (and two semi-synthetic d...
Silva, Ellen Cristina Costa; Coelho Cavalcanti, Bruno; Amorim, Rodrigo C.N.; Lucena, Jorcilene F.; Quadros, Dulcimar S.; Tadei, Wanderli PedroIn the present study, in vitro techniques were used to investigate a range of biological activities of known natural quassinoids isobrucein B (1) and neosergeolide (2), known semi-synthetic derivative 1,12-diacetylisobrucein B (3), and a new semi-synthetic derivative, 12-acetylneosergeolide (4). These compounds were evaluated for general toxicity toward the brine shrimp species Artemia franciscana, cytotoxicity...
Mebendazole induces apoptosis via C-MYC inactivation in malignant ascites cell ...
Pinto, Laine Celestino; Mesquita, Felipe Pantoja; Soares, Bruno Moreira; Silva, Emerson Lucena da; Puty, Bruna; Oliveira, Edivaldo Herculano Correa deFederal University of Par?. Biological Science Institute. Laboratory of Experimental Neuropathology. Bel?m, PA, Brazil.; Federal University of Cear?. Drug Research and Development Center. Laboratory of Pharmacogenetics. Fortaleza, CE, Brazil.; Federal University of Par?. Biological Science Institute. Laboratory of Human Cytogenetics. Bel?m, PA, Brazil.; Federal University of Cear?. Drug Research and Development...
Organic effects of associating paclitaxel with a lipid-based nanoparticle syste...
Feio, Danielle Cristinne Azevedo; Oliveira, Nayara Cristina Lima de; Pereira, Edmundo Luis Rodrigues; Morikawa, Aleksandra TiemiLipid-based nanoparticle systems have been used as vehicles for chemotherapeutic agents in experimental cancer treatments. Those systems have generally been credited with attenuating the severe toxicity of chemotherapeutic agents. This study aimed to investigate the effects of associating paclitaxel (PTX) with a lipid-based nanoparticle system on a nonhuman primate, Cebus apella, documenting the toxicity as mea...
Organic effects of associating paclitaxel with a lipid-based nanoparticle syste...
Feio, Danielle Cristina Azevedo; Oliveira, Nayara Cristina Lima de; Pereira, Edmundo Luis Rodrigues; Morikawa, Aleksandra TiemiFederal University of Par?. Institute of Biological Sciences. Human Cytogenetics Laboratory. Bel?m, PA, Brazil.; Federal University of Par?. Institute of Biological Sciences. Human Cytogenetics Laboratory. Bel?m, PA, Brazil.; Federal University of Par?. Institute of Biological Sciences. Human Cytogenetics Laboratory. Bel?m, PA, Brazil.; University of S?o Paulo. Heart Institute. Medical School Hospital. S?o Paul...
Synthesis and biological evaluation of novel 6-Hydroxy-benzo[d][1,3]oxathiol-2-...
Chazin, Eliza de Lucas; Sanches, Paola de Souza; Lindgren, Eric Brazil; Vellasco Júnior, Walcimar Trindade; Pinto, Laine CelestinoWith the aim of discovering new anticancer agents, we have designed and synthesized novel 6-hydroxy-benzo[d][1,3]oxathiol-2-one Schiff bases. The synthesis started with the selective nitration at 5-position of 6-hydroxybenzo[d][1,3]oxathiol-2-one (1) leading to the nitro derivative 2. The nitro group of 2 was reduced to give the amino intermediate 3. Schiff bases 4a–r were obtained from coupling reactions betwe...