Background: Post-bariatric weight loss varies substantially, and a large proportion of patients respond poorly. The literature highlights the importance of chrono-nutrition for weight regulation. This study aims to explore the chrono-related factors associated with poorer weight loss. Methods: This study was conducted within the ChronoWise project, an ongoing prospective cohort study following patients undergoi...
Background and aims: Bisphenol A (BPA), an endocrine disruptor widely used in food contact materials, has been linked to a worse health pro file. This study intends to estimate the association between BPA exposure and cardiometabolic patterns at adolescence. Methods and results: Data from the Portuguese population -based birth cohort Generation XXI at the age of 13 were used (n = 2386 providing 3 -day food diar...
Supervised learning has reached a bottleneck as they require expensive and time-consuming annotations. In addition, in some problems, such as in industrial spaces, it is not always possible to acquire a large number of images. Self-supervised learning helps these issues by extracting information from the data itself, without requiring labels and has achieved good performance, closing the gap between supervised ...
Group B Streptococcus (GBS) is the leading cause of meningitis in neonates. We have previously shown that plasminogen, once recruited to the GBS cell surface and converted into plasmin by host-derived activators, leads to an enhancement of bacterial virulence. Here, we investigated whether plasmin(ogen) bound at the GBS surface contributes to blood-brain barrier penetration and invasion of the central nervous s...