6 documents found, page 1 of 1
DOIS NOVOS ALCALOIDES AZAFENANTRENO DE Anaxagorea dolichocarpa Sprague & Sa...
Sales,Kaio A.; Pinheiro,Anderson A. V.; Araújo,Diego I. A. F.; Andrade,Rodrigo S. de; Agra,Maria de Fátima; Sobral,Marianna V.; Magalhães,Hemerson I. F.A chemical investigation of Anaxagorea dolichocarpa Sprague & Sandwith, a member of Annonaceae family, was carried out. The ethanolic extract from the roots of this plant led, by chromatography tecniches, to isolation of the new azaphenanthrene alkaloids dolichocarpine (1) and 9-methoxyeupolauramine (2), besides the known alkaloids eupolauramine (3), 3-methoxyeupolauridine (4), eupolauramine (5) and 4-methylsam...
Multielement Determination of Macro and Micro Contents in Medicinal Plants and ...
Santos Júnior,Aníbal de F.; Matos,Rafael A.; Andrade,Eberson M. J.; Santos,Walter N. L. dos; Magalhães,Hemerson I. F.; Costa,Fernanda do N.In this study, the elemental composition of nine medicinal plants and phytomedicines was evaluated by using axial view inductively coupled plasma optical emission spectrometry (ICP OES) after three digestion procedures: dry ashing (DA) and two wet digestions with a mineral acid (HNO3/H2O2) mixture on a conventional hot plate (CD), besides microwave digestion (MW). Accuracy was assessed from spinach leaves (CRM ...
In vitro Monitoring of Macro and Microelements in Multimineral Preparations acr...
Santos Júnior,Aníbal de F.; Sá,Ramon R.; Silva,Laiana O. B.; Magalhães,Hemerson I. F.; Tarantino,Taiana B.; Korn,Maria Graças A.In this study, inductively coupled plasma optical emission spectrometry (ICP OES) was used for multi-element analysis in five multimineral preparations from a dissolution test, in accordance with the United States Pharmacopeia (USP 34 method): apparatus 1, 75 rpm and 900 mL of 0.1 mol L-1 HCl. Element releases in all samples (minimum-maximum in %) were: Ca (14.5-28.2), Cr (54.5-68.0), Cu (2.9-10.0), Fe (4.0-34....
Potent antileukemic action of naphthoquinoidal compounds: evidence for an intri...
Cavalcanti,Bruno C.; Cabral,Igor O.; Rodrigues,Felipe A. R.; Barros,Francisco W. A.; Rocha,Danilo D.; Magalhães,Hemerson I. F.; Moura,Dinara J.The current study describes that nor-β-lapachone and its arylamino derivatives, iodinated and methylated naphthoquinones and nor-β-lapachone-based 1,2,3-triazoles exhibited pronounced cytotoxic effects against four human leukemia cell lines (HL-60, K562, Molt-4 and Jurkat). Nor-β-lapachones arylamino substituted with potent activity were identified, revealing themselves as potential prototypes against tumor cel...
In vitro cytotoxic activity of Brazilian Middle West plant extracts
Mahmoud,Talal Suleiman; Marques,Maria Rita; Pessoa,Cláudia do Ó; Lotufo,Leticia V. C.; Magalhães,Hemerson I. F.; Moraes,Manoel O. de; Lima,Dênis P. deCytotoxic activity of eight plant extracts, native from the Mid-West of Brazil comprising Cerrado, Pantanal and semideciduous forest, was evaluated for MDA-MB-435, SF-295, and HCT-8 cancer cell strains. A single 100 µg.mL-1 dose of each extract was employed with 72 h of incubation for all tests. Doxorubicin (1 µg.mL-1) was used as the positive control and the MTT method was used to detect the activity. Cytotoxi...
Estudo fitoquímico de Auxemma glazioviana Taub.
Costa,J. Galberto M.; Magalhães,Hemerson I. F.; Lemos,Telma L. G.; Pessoa,Otília D. L.; Pinheiro,Gilvandete M.Phytochemical investigation of heartwood of Auxemma glazioviana (Boraginaceae) has led to the isolation of three benzoquinones, one hydroquinone identified as: oncocalyxone A (1), oncocalyxone C (2), glazioviana A (3), glaziovianol (4) besides allantoin (5) α-bisabolol (6) and α-cadinol (7). Their structures were determined based on spectral analysis, including 2D NMR experiments. Essential oil obtained from he...