6 documents found, page 1 of 1
Potential chemoprotective effects of green propolis, L-lysine and celecoxib on ...
Dornelas,Conceição Aparecida; Cavalcanti,Bruno Coelho; Magalhães,Hemerson Iury Ferreira; Jamacaru,Francisco Vagnaldo FechinePURPOSE:To evaluate the genotoxicity of propolis and L-lysine, as well as their effects on the possible cellular damage in erythroblasts (bone marrow) and leukocytes (peripheral blood) caused by the carcinogen BBN (n - butyl - n {4 - hydroxybutyl} nitrosamine) in rats subjected to bladder carcinogenesis and treated with green propolis and L-lysine.METHODS: One hundred and twenty five rats were distributed into ...
Susceptibility to amphotericin B of Candida spp. strains isolated in Ceará, Nor...
Silva,Cecília Rocha da; Magalhães,Hemerson Iury Ferreira; Moraes,Manoel Odorico de; Nobre Júnior,Hélio VitorianoIntroductionAmphotericin B (AMB) is an antifungal agent used extensively in clinical medicine, yet resistance remains low. This study aims to evaluate the susceptibility of Candida spp. against AMB.MethodsFor broth microdilution susceptibility testing, 77 strains of Candida spp. were selected (32 C. albicans, 33 C. tropicalis, and 12 C. parapsilosis). The strains were considered susceptible when they exhibited ...
Chemoprevention with green propolis green propolis extracted in L-lysine versus...
Dornelas,Conceição Aparecida; Fechine-Jamacaru,Francisco Vagnaldo; Albuquerque,Irineu Lima; Magalhães,Hemerson Iury FerreiraPURPOSE: To determine the effects of green propolis extracted in L-lysine (WSDP) and of L- lysine for 40 weeks on induced rat bladder carcinogenesis. METHODS: The animals (groups I, II, III, IV, V and VI) received BBN during 14 weeks. Group I was treated with propolis 30 days prior received BBN, and then these animals were treated daily with propolis; Groups II and III was treated with subcutaneous and oral pro...
Angiogenesis inhibition by green propolis and the angiogenic effect of L-lysine...
Dornelas,Conceição Aparecida; Fechine-Jamacaru,Francisco Vagnaldo; Albuquerque,Irineu Lima; Magalhães,Hemerson Iury Ferreira; Dias,Thiago AlvesPURPOSE: To determine the effects of water-soluble derivative of green propolis in bladder cancer angiogenesis in rats given N-butyl-(-4-hydroxybutyl) nitrosamine (BBN). METHODS: Nine groups were established, where six of them (Groups 1 to 6), the animals received 0.05% BBN in their drinking water for 14 weeks. From the 32nd to the 40th week, Groups 1, 2, 3 and 4 were treated respectively with water, L-lysine (...
Analysis of oxidative status and biochemical parameters in adult patients with ...
Neto,Paulo Florentino Teixeira; Gonçalves,Romélia Pinheiro; Elias,Darcielle Bruna Dias; Araújo,Cleiton Pinheiro de; Magalhães,Hemerson Iury FerreiraBACKGROUND: Sickle cell anemia is a hemoglobinopathy caused by a mutation that results in the production of an abnormal hemoglobin molecule, hemoglobin S (Hb S). This is responsible for profound physiological changes, such as the sickling of red blood cells. Several studies have shown that hydroxyurea protects against vaso-occlusive crises. OBJECTIVE: The aim of this study was to evaluate the oxidative stress a...
Constituintes químicos de Parmotrema lichexanthonicum Eliasaro & Adler: iso...
Micheletti,Ana C.; Beatriz,Adilson; Lima,Dênis Pires de; Honda,Neli K.; Pessoa,Cláudia do Ó; Moraes,Manoel Odorico de; Lotufo,Letícia VerasFrom the lichen Parmotrema lichexantonicum were isolated the depsidone salazinic acid, the xanthone lichexanthone, and the depside atranorin. The two major compounds, salazinic acid and lichexanthone, were selected for structure modifications. Salazinic acid afforded O-alkyl salazinic acids, some of them potentially cytotoxic against tumor cell lines (HCT-8, SF-295 and MDA/ MB - 435). From lichexanthone were ob...