3 documents found, page 1 of 1
Splicing factor SF3B1 mutations and ring sideroblasts in myelodysplastic syndro...
Donaires,Flávia Sacilotto; Martelli,Felipe; Alves-Paiva,Raquel de Melo; Magalhães,Silvia Maria Meira; Pinheiro,Ronald Feitosa; Calado,Rodrigo TocantinsABSTRACT Background: Myelodysplastic syndromes (MDS) comprise a group of malignant clonal hematologic disorders characterized by ineffective hematopoiesis and propensity for progression to acute myeloid leukemia. Acquired mutations in the gene encoding RNA splicing factor 3B subunit 1 (SF3B1) are highly associated with the MDS subtypes presenting ring sideroblasts, and represent a specific nosological entity. T...
Evaluation of the concentration of malondialdehyde and nitrite in patients with...
Elias,Darcielle Bruna Dias; Freitas,Rivelilson Mendes de; Gonçalves,Romélia Pinheiro; Magalhães,Hemerson Yuri Ferreira; Sousa,Jacqueline Holanda deABSTRACT Objective: To determine the serum levels of malondialdehyde and nitrite in patients with sickle cell anemia treated or not with hydroxyurea in outpatient's setting. Methods: Of the 65 patients with sickle cell anemia selected for the study, 51 were not treated with hydroxyurea (Group 1), 14 made chronic use of hydroxyurea (Group 2) and 20 individuals had no hemoglobinopathies (Control Group). Results: ...
Analysis of the association between Epstein-Barr virus and classic Hodgkins ly...
Pinto,Marília Taumaturgo; Ferreira,Francisco Valdeci de Almeida; Pitombeira,Maria da Silva; Magalhães,Silvia Maria MeiraThe prevalence of Epstein-Barr virus (EBV) in patients with classical Hodgkins lymphoma (CHL) is geographically variable. In the present study the prevalence of EBV in CHL was assessed in adult patients from Ceará, Brazil. Thirty-seven cases were immunohistochemically evaluated for EBV using latent membrane protein (LMP1) antibody and for EBV latency-associated RNA (EBER1) using in situ hybridization (ISH). Se...