3 documents found, page 1 of 1
Adenosinergic system and BDNF signaling changes as a cross-sectional feature of...
Miranda-Lourenço, Catarina; Rosa, Jéssica; Rei, Nádia; Belo, Rita F.; Lopes, Ana Luísa; Silva, Diogo; Vieira, Cátia; Magalhães-Cardoso, TeresaRett Syndrome is an X-linked neurodevelopmental disorder (RTT; OMIM#312750) associated to MECP2 mutations. MeCP2 dysfunction is seen as one cause for the deficiencies found in brain-derived neurotrophic factor (BDNF) signaling, since BDNF is one of the genes under MeCP2 jurisdiction. BDNF signaling is also dependent on the proper function of the adenosinergic system. Indeed, both BDNF signaling and the adenosin...
Opposing Effects of Adenosine and Inosine in Human Subcutaneous Fibroblasts May...
Herman-de-Sousa, Carina; Pinheiro, Ana Rita; Paramos-de-Carvalho, Diogo; Costa, Maria Adelina; Ferreirinha, Fátima; Magalhães-Cardoso, TeresaHuman subcutaneous fibroblasts (HSCF) challenged with inflammatory mediators release huge amounts of ATP, which rapidly generates adenosine. Given the nucleoside's putative relevance in wound healing, dermal fibrosis, and myofascial pain, we investigated the role of its precursor, AMP, and of its metabolite, inosine, in HSCF cells growth and collagen production. AMP (30 µM) was rapidly (t½ 3 ± 1 min) dephosphor...
Impairment of adenosinergic system in Rett syndrome: novel therapeutic target t...
Miranda-Lourenço, Catarina; Duarte, Sofia T.; Palminha, Cátia; Gaspar, Cláudia; Rodrigues, Tiago M.; Magalhães-Cardoso, Teresa; Rei, NádiaRett syndrome (RTT; OMIM#312750) is mainly caused by mutations in the X-linked MECP2 gene (methyl-CpG-binding protein 2 gene; OMIM*300005), which leads to impairments in the brain-derived neurotrophic factor (BDNF) signalling. The boost of BDNF mediated effects would be a significant breakthrough but it has been hampered by the difficulty to administer BDNF to the central nervous system. Adenosine, an endogenou...