6 documents found, page 1 of 1
Investigation of the Chemiluminescent Reaction of a Fluorinated Analog of Marin...
Magalhaes, CM; da Silva, JCGE; da Silva, LPBioluminescence (BL) and chemiluminescence (CL) are remarkable processes in which light is emitted due to (bio)chemical reactions. These reactions have attracted significant attention for various applications, such as biosensing, bioimaging, and biomedicine. Some of the most relevant and well-studied BL/CL systems are that of marine imidazopyrazine-based compounds, among which Coelenterazine is a prime example....
Comparative investigation into the anticancer activity of analogs of marine coe...
Magalhaes, CM; Pereira, RB; Erbiai, E; González Berdullas, P; Joaquim C G E Esteves da Silva; Pereira, DM; da Silva, LPCancer is still one of the most challenging diseases to treat, making the pursuit for novel molecules with potential anticancer activity an important research topic. Herein, we have performed a comparative investigation into the anticancer activity of analogs of marine coelenterazine and coelenteramine. The former is a well-known bioluminescent substrate, while the latter is a metabolic product of the resulting...
Synchrotron-based FTIR evaluation of biochemical changes in cancer and noncance...
Magalhaes, CM; Ducic, T; Pereira, RB; Gonzalez-Berdullas, P; Rodriguez Borges, JE; Pereira, DM; Joaquim C G E Esteves da Silva; Algarra, M; da Silva, LPThe mode of action toward gastric cancer cells of brominated Coelenteramine, an analogue of a metabolic product of a marine bioluminescent reaction, was investigated by synchrotron radiation-based Fourier Transform Infrared spectrocopy (FTIR). This method revealed that the anticancer activity of brominated Coelenteramine is closely connected with cellular lipids, by affecting their organization and composition....
Investigation of the Anticancer and Drug Combination Potential of Brominated Co...
Magalhaes, CM; Gonzalez-Berdullas, P; Pereira, M; Duarte, D; Nuno Vale; Joaquim C G E Esteves da Silva; da Silva, LPCancer is a very challenging disease to treat, both in terms of therapeutic efficiency and harmful side effects, which continues to motivate the pursuit for novel molecules with potential anticancer activity. Herein, we have designed, synthesized, and evaluated the cytotoxicity of different brominated coelenteramines, which are metabolic products and synthesis precursors of the chemi-/bioluminescent system of m...
Elucidating the chemiexcitation of dioxetanones by replacing the peroxide bond ...
Magalhaes, CM; Gonzalez Berdullas, P; Joaquim C G E Esteves da Silva; da Silva, LPDioxetanone is one of the prototypical cyclic peroxide intermediates in several chemiluminescent and bioluminescent systems, in which thermolysis reactions allow efficient singlet chemiexcitation. While the chemiexcitation mechanism of dioxetanone and peroxide intermediates is still far from understood, the presence of a peroxide bond that undergoes bond breaking has been found to be a constant. Here we have ad...
Target-Oriented Synthesis of Marine Coelenterazine Derivatives with Anticancer ...
Magalhaes, CM; Gonzalez Berdullas, P; Duarte, D; Correia, AS; Rodriguez Borges, JE; Nuno Vale; Joaquim C G E Esteves da Silva; da Silva, LPPhotodynamic therapy (PDT) is an anticancer therapeutic modality with remarkable advantages over more conventional approaches. However, PDT is greatly limited by its dependence on external light sources. Given this, PDT would benefit from new systems capable of a light-free and intracellular photodynamic effect. Herein, we evaluated the heavy-atom effect as a strategy to provide anticancer activity to derivativ...