Deep brain stimulation (DBS) is a well-established surgical treatment for Parkinson’s disease. Peri-lead edema (PLE) is a poorly understood complication of DBS. We hereby report three cases of unilateral PLE after bilateral subthalamic nucleus (STN)-DBS and discuss its diagnosis and management. Patient 1 reported a new-onset headache one month after his surgical procedure. Antibiotic treatment was administered....