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Parental infertility and offspring cardiometabolic trajectories: a pooled analy...

Hernáez, Á; Elhakeem, A; Barros, H; Vrijkotte, TGM; Fraser, A; Lawlor, DA; Magnus, MC

Objective To assess whether parental infertility is associated with differences in cardiometabolic trajectories in offspring. Design Pooled observational analysis in three prospective cohorts. Setting Three nationwide pregnancy cohorts. Patients A total of 14,609 singletons from the UK Avon Longitudinal Study of Parents and Children, the Portuguese Geraçao 21, and the Amsterdam Born Children and Their Developme...


Long-term cardiometabolic health in people born after assisted reproductive tec...

Elhakeem, A; Taylor, AE; Inskip, HM; Huang, JY; Mansell, T; Rodrigues, C; Asta, F; Blaauwendraad, SM; Haberg, SE; Halliday, J; Harskamp-van Ginkel, MW

Aims To examine associations of assisted reproductive technology (ART) conception (vs. natural conception: NC) with offspring cardiometabolic health outcomes and whether these differ with age. Methods and results Differences in systolic (SBP) and diastolic blood pressure (DBP), heart rate (HR), lipids, and hyperglycaemic/insulin resistance markers were examined using multiple linear regression models in 14 popu...


Early-life respiratory tract infections and the risk of school-age lower lung f...

van Meel, ER; Mensink-Bout, SM; den Dekker, HT; Ahluwalia, TS; Annesi-Maesano, I; Arshad, SH; Baïz, N; Barros, H; von Berg, A; Bisgaard, H

Background Early-life respiratory tract infections might affect chronic obstructive respiratory diseases, but conclusive studies from general populations are lacking. Our objective was to examine if children with early-life respiratory tract infections had increased risks of lower lung function and asthma at school age. Methods We used individual participant data of 150 090 children primarily from the EU Child ...


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