4 documents found, page 1 of 1
Neuro-mesenchymal units control ILC2 and obesity via a brain–adipose circuit
Cardoso, Ana; Klein Wolterink, Roel G. J.; Godinho-Silva, Cristina; Domingues, Rita G.; Ribeiro, Hélder; da Silva, Joaquim Alves; Mahú, InêsSignals from sympathetic neurons and immune cells regulate adipocytes and thereby contribute to fat tissue biology. Interactions between the nervous and immune systems have recently emerged as important regulators of host defence and inflammation1-4. Nevertheless, it is unclear whether neuronal and immune cells co-operate in brain-body axes to orchestrate metabolism and obesity. Here we describe a neuro-mesench...
Brain-sparing sympathofacilitators mitigate obesity without adverse cardiovascu...
Mahú, Inês; Barateiro, Andreia; Rial-Pensado, Eva; Martinéz-Sánchez, Noelia; Vaz, Sandra H.; Cal, Pedro M.S.D.; Jenkins, Benjamin; Rodrigues, Tiago M.Anti-obesity drugs in the amphetamine (AMPH) class act in the brain to reduce appetite and increase locomotion. They are also characterized by adverse cardiovascular effects with origin that, despite absence of any in vivo evidence, is attributed to a direct sympathomimetic action in the heart. Here, we show that the cardiac side effects of AMPH originate from the brain and can be circumvented by PEGylation (PE...
Determining the role of Sympathetic Nervous System Activity in the control of B...
Mahú, Inês"Some humans resist fat gain with overeating, whereas others easily store excess weight (Riveros-McKay et al., 2019). The possibility that differences in the thermogenesis could underlie the susceptibility to obesity was first proposed over a century ago (Neumann, 1902), a phenomenon controlled by the elevation of sympathetic-nervous-system (SNS) activity (Schwartz et al., 1983). We first developed a model of l...
A brain-sparing diphtheria toxin for chemical genetic ablation of peripheral ce...
Pereira, Mafalda M. A.; Mahú, Inês; Seixas, Elsa; Martinéz-Sánchez, Noelia; Kubasova, Nadiya; Pirzgalska, Roksana M; Cohen, Paul; Dietrich, Marcelo OConditional expression of diphtheria toxin receptor (DTR) is widely used for tissue-specific ablation of cells. However, diphtheria toxin (DT) crosses the blood-brain barrier, which limits its utility for ablating peripheral cells using Cre drivers that are also expressed in the central nervous system (CNS). Here we report the development of a brain-sparing DT, termed BRAINSPAReDT, for tissue-specific genetic a...