5 documents found, page 1 of 1
Biofate and cellular interactions of lipid nanoparticles
Baldim, Iara; Oliveira, Wanderley P.; Rao, Rekha; Raghuvir, Singh; Mahant, Sheefali; Gama, F. M.; Souto, Eliana B.By definition, drug targeting and delivery is the process of delivering a drug molecule to a specific site where the pharmacological effect is desired. A targeted release may simplify the drug administration protocols and reduce the amount of drug necessary, thus improving the cost-effectiveness and reducing the side effects. A drug administered by intravenous injection distributes in the whole body, reaching o...
Natural ergot alkaloids in ocular pharmacotherapy: known molecules for novel na...
Baldim, Iara; Oliveira, Wanderley P.; Kadian, Varsha; Rao, Rekha; Yadav, Nitesh; Mahant, Sheefali; Lucarini, Massimo; Durazzo, AlessandraSeveral pharmacological properties are attributed to ergot alkaloids as a result of their antibacterial, antiproliferative, and antioxidant effects. Although known for their biomedical applications (e.g., for the treatment of glaucoma), most ergot alkaloids exhibit high toxicological risk and may even be lethal to humans and animals. Their pharmacological profile results from the structural similarity between l...
SLN and NLC for topical, dermal, and transdermal drug delivery
Souto, Eliana B.; Baldim, Iara; Oliveira, Wanderley P.; Rao, Rekha; Yadav, Nitesh; Gama, F. M.; Mahant, SheefaliIntroduction: From a biopharmaceutical standpoint, the skin is recognized as an interesting route for drug delivery. In general, small molecules are able to penetrate the stratum corneum, the outermost layer of the skin. In contrast, the delivery of larger molecules, such as peptides and proteins, remains a challenge. Nanoparticles have been exploited not only to enhance skin penetration of drugs but also to ex...
Analytical tools and evaluation strategies for nanostructured lipid carrier-bas...
Mahant, Sheefali; Rao, Rekha; Souto, Eliana B.; Nanda, SanjuIntroduction The inception of nanostructured lipid carriers (NLCs) proved to be a revolutionary step toward the treatment of dermatological disorders. To uncover its true potential, it is imperative that the system be characterized and evaluated comprehensively. Areas covered The present review has been written to furnish an in-depth account of analytical tools and evaluation procedures under one roof. Besides ...
Therapeutic interventions for countering Leishmaniasis and Chagas's disease: fr...
Souto, Eliana B.; Dias-Ferreira, João; Craveiro, Sara A.; Severino, Patrícia; Sanchez-Lopez, Elena; Garcia, Maria L.; Silva, Amélia M.; Souto, Selma B.The incidence of neglected diseases in tropical countries, such as Leishmaniasis and Chagass disease, is attributed to a set of biological and ecological factors associated with the socioeconomic context of developing countries and with a significant burden to health care systems. Both Leishmaniasis and Chagass disease are caused by different protozoa and develop diverse symptoms, which depend on the specific s...