High flow nasal cannula oxygen therapy represents an important alternative in non-invasive ventilatory support for patients with acute respiratory failure. This article aims to review the main physiological effects of the technique and the studies that support its use in diverse underlying conditions. Due to its excellent tolerability and efficacy in cases of hypoxemic respiratory failure, it may become a first...
Levosimendan was first approved for clinical use in 2000, when authorization was granted by Swedish regulatory authorities for the hemodynamic stabilization of patients with acutely decompensated chronic heart failure (HF). In the ensuing 20 years, this distinctive inodilator, which enhances cardiac contractility through calcium sensitization and promotes vasodilatation through the opening of adenosine triphosp...