14 documents found, page 1 of 2
Serum amyloid A proteins reduce bone mass during mycobacterial infections
Gomes, AC; Sousa, DM; Oliveira, TC; Fonseca, O; Pinto, RJ; Silvério, D; Fernandes, AI; Moreira, AC; Silva, T; Teles, MJ; Pereira, L; Saraiva, MIntroductionOsteopenia has been associated to several inflammatory conditions, including mycobacterial infections. How mycobacteria cause bone loss remains elusive, but direct bone infection may not be required. MethodsGenetically engineered mice and morphometric, transcriptomic, and functional analyses were used. Additionally, inflammatory mediators and bone turnover markers were measured in the serum of healt...
InfectionCMA: A Cell MicroArray Approach for Efficient Biomarker Screening in I...
Magalhães, AC; Ricardo, S; Moreira, AC; Nunes, M; Tavares, M; Pinto, RJ; Gomes, MS; Pereira, LThe recently emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has forced the scientific community to acquire knowledge in real-time, when total lockdowns and the interruption of flights severely limited access to reagents as the global pandemic became established. This unique reality made researchers aware of the importance of designing efficient in vitro set-ups to evaluate infectious kinet...
Iron Related Biomarkers Predict Disease Severity in a Cohort of Portuguese Adul...
Moreira, AC; Teles, MJ; Silva, T; Bento, CM; Alves, IS; Pereira, L; Guimarães, JT; Porto, G; Oliveira, P; Gomes, MSLarge variability in COVID-19 clinical progression urges the need to find the most relevant biomarkers to predict patients’ outcomes. We evaluated iron metabolism and immune response in 303 patients admitted to the main hospital of the northern region of Portugal with variable clinical pictures, from September to November 2020. One hundred and twenty-seven tested positive for SARS-CoV-2 and 176 tested negative....
Dynamics of a Dual SARS-CoV-2 Lineage Co-Infection on a Prolonged Viral Sheddin...
Pedro, N; Silva, CN; Magalhães, AC; Cavadas, B; Rocha, AM; Moreira, AC; Gomes, MS; Silva, D; Sobrinho-Simões, J; Ramos, A; Cardoso, MJ; Filipe, RA few molecularly proven severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cases of symptomatic reinfection are currently known worldwide, with a resolved first infection followed by a second infection after a 48 to 142-day intervening period. We report a multiple-component study of a clinically severe and prolonged viral shedding coronavirus disease 2019 (COVID-19) case in a 17-year-old Portuguese f...
Phenolic Bioactives as Antiplatelet Aggregation Factors: The Pivotal Ingredient...
Sharifi-Rad, J; Quispe, C; Zam, W; Kumar, M; Cardoso, SM; Pereira, OR; Ademiluyi, AO; Adeleke, O; Moreira, AC; Živkovic, J; Noriega, F; Ayatollahi, SACardiovascular diseases (CVD) are one of the main causes of mortality in the world. The development of these diseases has a specific factor-alteration in blood platelet activation. It has been shown that phenolic compounds have antiplatelet aggregation abilities and a positive impact in the management of CVD, exerting prominent antioxidant, anti-inflammatory, antitumor, cardioprotective, antihyperglycemic, and ...
Dynamics of a dual sars-cov-2 lineage co-infection on a prolonged viral sheddin...
Pedro, N; Silva, CN; Magalhães, AC; Cavadas, B; Rocha, AM; Moreira, AC; Gomes, MS; Silva, D; Sobrinho-Simões, J; Ramos, A; Cardoso, MJ; Filipe, RA few molecularly proven severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cases of symptomatic reinfection are currently known worldwide, with a resolved first infection followed by a second infection after a 48 to 142-day intervening period. We report a multiplecomponent study of a clinically severe and prolonged viral shedding coronavirus disease 2019 (COVID-19) case in a 17-year-old Portuguese fe...
H-Ferritin Is Essential for Macrophages' Capacity to Store or Detoxify Exogenou...
Mesquita, G; Silva, T; Gomes, AC; Oliveira, PF; Alves, MG; Fernandes, R; Almeida, AA; Moreira, AC; Gomes, MSMacrophages are central cells both in the immune response and in iron homeostasis. Iron is both essential and potentially toxic. Therefore, iron acquisition, transport, storage, and release are tightly regulated, by several important proteins. Cytosolic ferritin is an iron storage protein composed of 24 subunits of either the L- or the H-type chains. H-ferritin differs from L-ferritin in the capacity to oxidize...
Impact of natural compounds on neurodegenerative disorders: From preclinical to...
Sharifi-Rad, M; Lankatillake, C; Dias, DA; Docea, AO; Mahomoodally, MF; Lobine, D; Chazot, PL; Kurt, B; Tumer, TB; Moreira, AC; Sharopov, FAmong the major neurodegenerative disorders (NDDs), Alzheimer’s disease (AD) and Parkinson’s disease (PD), are a huge socioeconomic burden. Over many centuries, people have sought a cure for NDDs from the natural herbals. Many medicinal plants and their secondary metabolites are reported with the ability to alleviate the symptoms of NDDs. The major mechanisms identified, through which phytochemicals exert their...
Evolution of Resting Energy Expenditure, Respiratory Quotient, and Adiposity in...
Pereira-da-Silva, L; Barradas, S; Moreira, AC; Alves, M; Papoila, AL; Virella, D; Cordeiro-Ferreira, GThis cohort study describes the evolution of resting energy expenditure (REE), respiratory quotient (RQ), and adiposity in infants recovering from corrective surgery of major congenital gastrointestinal tract anomalies. Energy and macronutrient intakes were assessed. The REE and RQ were assessed by indirect calorimetry, and fat mass index (FMI) was assessed by air displacement plethysmography. Longitudinal vari...
Modulation of iron metabolism in response to infection: Twists for all tastes
Gomes, AC; Moreira, AC; Mesquita, G; Gomes, MSIron is an essential nutrient for almost all living organisms, but is not easily made available. Hosts and pathogens engage in a fight for the metal during an infection, leading to major alterations in the host’s iron metabolism. Important pathological consequences can emerge from the mentioned interaction, including anemia. Several recent reports have highlighted the alterations in iron metabolism caused by di...