8 documents found, page 1 of 1
Epidemiological and clinical aspects of Cutaneous and Mucosal Leishmaniases in ...
Rocha, Rafael; Conceição, Cláudia; Gonçalves, Luzia; Carvalho, Ana Cláudia; Maia, André; Martins, André; Carujo, António; Maio, António; Forra, CatarinaLeishmania infantum, a zoonotic vector-born parasite, is endemic in the Mediterranean region, presenting mostly as visceral (VL), but also as cutaneous (CL) and mucosal leishmaniasis (ML). This study aimed to describe the epidemiological and clinical aspects of the CL and ML cases diagnosed in mainland Portugal between 2010 and 2020. Collaboration was requested from every hospital of the Portuguese National Hea...
Steroid–quinoline hybrids for disruption and reversion of protein aggregation p...
Albuquerque, Hélio; Silva, Raquel Nunes da; Pereira, Marisa; Maia, André; Guieu, Samuel; Soares, Ana Raquel; Santos, Clementina M.M.; Vieira, Sandra I.Reversing protein aggregation within cells may be an important tool to fight protein-misfolding disorders such as Alzheimer’s, Parkinson’s, and cardiovascular diseases. Here we report the design and synthesis of a family of steroid−quinoline hybrid compounds based on the framework combination approach. This set of hybrid compounds effectively inhibited Aβ1−42 self-aggregation in vitro by delaying the exponentia...
Liprobe, a vital dye for lipid aggregates detection in imaging and high-content...
Vieira, Sandra I.; Nunes da Silva, Raquel; Alves, Mariana; Dias, Roberto A.; Meireles Sousa, Ana M.; Camões, Fatima; Maia, André; Almeida, MónicaPathological lipid accumulation is a hallmark of several metabolic disorders, and detection of lipid aggregates is an essential step for initial diagnosis and drug screening purposes. However, low-cost, simple, and reliable detection fluorescent probes are not widely available. Here, six push-pull-push dyes were studied, and proved to be highly sensitive to the polarity of the medium, presenting potential to di...
Plano de Ação para Reabilitação de Doentes com COVID-19 Admitidos em Unidade de...
Aguiar Branco, Catarina; Rocha, Afonso; Machado Vaz, Inês; Rios, Jonathan; Pinto, Anabela; Rolo Duarte, Ana; Henriques, Ricardo; Moreira, Jorge.; .
The value creation wheel: a meta-framework to create value for deimos group
Lima, Ana Teresa; Galhofo, João Tiago Martins; Maia, André; Maçãs, Margarida Isabel Duarte Martins; Margarido, Nina CésarIn this work, the spotlight was on Deimos Group, an Aerospace Engineering company. Starting with the concept of value, this work leads to an explanation of the Value Creation Wheel (VCW) framework and a description of the paradoxes it may solve. Five case studies demonstrate how the framework was applied, namely in: 1) Identifying and engaging new clients for the PDGS & Data Systems division, 2) Finding new use...
Caracterização e Análise do Sistema de Combustível do UAV ANTEX X-02
Maia, AndréEsta Dissertação de Tese de Mestrado surgiu enquadrada com as atividades de investigação e desenvolvimento levadas a cabo pelo Centro de Investigação da Academia da Força Aérea Portuguesa (CIAFA) no decorrer do PITVANT (Projeto de Investigação e Tecnologia em Veículos Aéreos Não-Tripulados). Neste projeto, foram desenvolvidos vários Veículos aéreos Não tripulados, entre os quais a plataforma Alfa-Extended, uma ...
Sign articulators: non-dominante hand
Campos, Adriana; Pedreira, Ana Cláudia; Maia, AndréThis article discusses the phonology of the Portuguese Sign Language, focusing on its manual articulators. Similarly to oral languages, which have the vocal tract as their main articulator, sign languages, with their manual-visual modality, have both hands. These are anatomically identical: the dominant hand and the non-dominant hand. This study addresses in detail the latter so as to understand its functioning...
Articuladores gestuais: mão não dominante
Campos, Adriana; Pedreira, Ana Cláudia; Maia, AndréEste artigo aborda a fonologia da Língua Gestual Portuguesa com enfoque nos articuladores gestuais. Analogamente às línguas orais que têm como articulador primordial o aparelho fonador, as línguas gestuais, sendo de modalidade gesto-visual, têm as duas mãos que são anatomicamente idênticas: a mão dominante e a mão não dominante. É sobre esta última que o estudo incidirá pormenorizadamente a fim de perceber o se...