10 documents found, page 1 of 1
Role of genetic polymorphisms on neuroplasticity pathways in a cohort of Portug...
Santos, M.; Carvalho, S.; Lima, L.; Mota-Pereira, J.; Pimentel, P.; Correia, D.; Maia, D.; Gomes, S.; Cruz, A.; Medeiros, R.Growing evidence suggests the implication of brain plasticity in antidepressant drug (AD) efficacy. Several authors have been pointing out the role of the BDNF-TrkB signaling pathway, including the downstream kinases Akt and ERK, and the mTOR pathway in neuroplasticity [1-3]. Furthermore, the prediction of AD response phenotypes of depressed patients treated with AD drugs remains a challenge for clinicians. Alt...
Square Kilometre Array Science Data Challenge 1: analysis and results
Bonaldi, A.; T. An; Bruggen, M.; Burkutean, S.; Coelho, B.; Goodarzi, H.; Hartley, P.; Sandhu, P. K.; Wu, C.; L. Yu; Haghighi, M. H. ZhoolidehAs the largest radio telescope in the world, the Square Kilometre Array (SKA) will lead the next generation of radio astronomy. The feats of engineering required to construct the telescope array will be matched only by the techniques developed to exploit the rich scientific value of the data. To drive forward the development of efficient and accurate analysis methods, we are designing a series of data challenge...
Handicap as a measure of perceived health status in Parkinson’s disease
Silva, D.; Coelho, M.; Soares, T.; Vale, T.; Guedes, L.; Maciel, R.; Antunes, A. P.; Camargos, S.; Valadas, A.; Godinho, Catarina; Maia, D.; Lobo, P. P.
Measuring perceived-health status in Parkinson’s Disease – the role of London H...
Silva, D.; Coelho, M.; Soares, T.; Vale, T.; Guedes, L.; Maciel, R.; Antunes, A.; Camargos, S.; Valadas, A.; Godinho, Catarina; Maia, D.; Lobo, P.
Portuguese consensus document for the management of alpha-1-antitrypsin deficiency
Lopes, A.P.; Mineiro, M.A.; Costa, F.; Gomes, J.; Santos, C.; Antunes, C.; Maia, D.; Melo, R.; Canotilho, M.; Magalhães, E.; Vicente, I.; Valente, C.Alpha-1-antitrypsin deficiency (AATD) is a genetic autosomal codominant disorder caused by mutations in SERPINA1 gene. It is one of the most prevalent genetic disorders, although it remains underdiagnosed. Whereas at international level there are several areas of consensus on this disorder, in Portugal, inter-hospital heterogeneity in clinical practice and resources available have been adding difficulties in re...
Portuguese consensus document for the management of alpha-1-antitrypsin deficiency
Lopes, A.; Mineiro, M.; Costa, F.; Gomes, J.; Santos, C.; Antunes, C.; Maia, D.; Melo, R.; Canotilho, M.; Magalhães, E.; Vicente, I.; Valente, C.Alpha-1-antitrypsin deficiency (AATD) is a genetic autosomal codominant disorder caused by mutations in SERPINA1 gene. It is one of the most prevalent genetic disorders, although it remains underdiagnosed. Whereas at international level there are several areas of consensus on this disorder, in Portugal, inter-hospital heterogeneity in clinical practice and resources available have been adding difficulties in re...
Very large scale high performance computing and instrument management for high ...
Morgado, J. B.; Maia, D.; Barbosa, D.; Barraca, J. P.; Bergano, J.; Bartashevich, D.; Silva, Nuno; Di Carlo, M.; Canzari, M.; Dolci, M.; Smareglia, R.The Square Kilometer Array (SKA) Telescope, is an ongoing project set to start its building phase in 2018 and be ready for first light in 2020. The first part of the project, the SKA1 will be comprised of 130.000 low frequency antennas (50 MHz to 350 MHz) and 200 mid frequency antennas (350 MHz to 15.5 GHz). The SKA1 will produce a raw data rate of ~10 Tb/s, require a computing power of 100 Pflop/s and an archi...
A Cyber Infrastructure for the SKA Telescope Manager
Barbosa, D; Barraca, J. P.; Carvalho, B.; Maia, D.; Gupta, Y.; Natarajan, S.; Le Roux, G.; Swart, P.The Square Kilometre Array Telescope Manager (SKA TM) will be responsible for assisting the SKA Operations and Observation Management, carrying out System diagnosis and collecting Monitoring & Control data from the SKA subsystems and components. To provide adequate compute resources, scalability, operation continuity and high availability, as well as strict Quality of Service, the TM cyber-infrastructure (embod...
Power Monitoring and Control for Large Scale projects: SKA, a case study
Barbosa, D; Barraca, J. P.; Maia, D.; Carvalho, B.; Vieira, J.; Swart, P.; Le Roux, G.; Natarajan, S.; van Ardenne, A.; Seca, L.Large sensor-based science infrastructures for radio astronomy like the SKA will be among the most intensive data driven projects in the world, facing very high demanding computation, storage, management, and above all power demands The geographically wide distribution of the SKA and and its associated processing requirements in the form of tailored High Performance Computing (HPC) facilities, require a Greener...
Influence of Il-18 genetic polymorphisms in antidepressant treatment phenotypes
Santos, Marlene; Carvalho, S.; Lima, L.; Mota-Pereira, J.; Pimentel, P.; Maia, D.; Correia, D.; Gomes, S.; Cruz, Agostinho; Medeiros, R.Recent studies suggested that immune activation and cytokines might be involved in depression. The proinflammatory cytokine interleukin-18 (IL-18) is less reported in depression but is still relevant since it is expressed in the brain and serum levels of IL-18 have been found to be increased in patients with moderate to severe depression. Therefore, it seems reasonable that IL-18 promoter SNPs may have an effec...